AKIT11

PKNH_0104800 (AKIT11) is a constituent of the apicomplexan kinetochore complex, identified in Plasmodium berghei as one of 13 previously unknown kinetochore components through interactomics combined with deep homology searches (PMID:36006241). Beyond this complex membership, no mechanistic detail about the specific function of PKNH_0104800 within the kinetochore has been characterized in the available corpus.

1. 2022 Medium

   The composition of the apicomplexan kinetochore was largely undefined; identifying its constituents established which proteins assemble at this structure, and placed PKNH_0104800 among them.

   Evidence Interactomics (co-immunoprecipitation/proximity-ligation-based proteomics) combined with deep homology searches in Plasmodium knowlesi

   PMID:36006241

   Open questions at the time

   • No functional dissection of PKNH_0104800 itself within the kinetochore
   • No direct binding partners or substructural position of PKNH_0104800 defined
   • Complex membership rests on a single interactomics study without independent validation

• The specific molecular role of PKNH_0104800 within the kinetochore, its direct interaction partners, and its contribution to chromosome segregation remain unknown.
• No knockout/knockdown phenotype for PKNH_0104800 reported
• No structural or biochemical characterization of PKNH_0104800
• No demonstrated role in kinetochore-microtubule attachment or mitotic progression