Affinage · Plasmodium

Stats

How the Plasmodium gene cards break down across species and against other organisms, how many carry a literature annotation, and what the extracted findings and compute spend look like.

6,740
Gene cards
Pf3D7 · PbANKA · PkH
10,885
Discoveries
avg 4.4 per annotated card
10,846
Source papers
distinct PMIDs in corpus
$265
Total spend
$0.039/card
Cards by species presence
6,740 cards · bar length = cards · annotated share in violet
Annotated Not annotated
All 3 species 1,967 of 4,414 · 45%
2 species 107 of 263 · 41%
1 species 360 of 1,994 · 18%
1 species · rRNA copies 51 of 69 · 74%
Single-species cards by species · rRNA copies excluded
SpeciesCardsAnnotated
Pf3D7 706 243
PbANKA 654 68
PkH 634 49

A card groups one gene's loci across P. falciparum (Pf3D7), P. berghei (PbANKA) and P. knowlesi (PkH) by OrthoMCL ortholog group. Single-species cards are not all species-specific genes: they include paralog copies and gene models from separate species annotations. rRNA copies are split out because the genome carries many rRNA loci and far more of them have literature than other single-species cards. Annotated = at least one finding from the reading pass.

Cross-species links
Confident 1:1 orthologs in Toxoplasma and human · bar length = cards
Annotated Not annotated
Toxoplasma and human 113 of 142 · 80%
Toxoplasma only 370 of 665 · 56%
Human only 191 of 334 · 57%
No confident 1:1 link 1,811 of 5,599 · 32%

A link is a confident one-to-one ortholog by reciprocal best hit: Toxoplasma gondii ME49 and the human proteome. Both are computed mainly from the Pf3D7 gene: of the 1,426 cards without a Pf3D7 locus, 29 have a Toxoplasma link and 12 a human link. No confident 1:1 link means no such match was found — not that the gene is unique to Plasmodium.

Discovery confidence
Tier × preponderance · 10,885 findings
High
3,082 · 28.3%
Medium
5,643 · 51.8%
Low
2,160 · 19.8%

Assigned per-finding by the reading pass from method tier and weight of evidence. High = direct biochemical/structural/genetic proof; Low = single-paper observational claim.

Discovery year histogram
10,879 dated findings · 1980 → 2026 · post-2020 in red
1980 2003 2026

≥ 2020: 3,229 findings (29.7% of dated).

Compute ledger
USD · batch rates · recorded per card by the pipeline
Full-genome annotation $265.12 6,740 cards · $0.039/card
Total LLM spend $265.12