AP2-O5
PF3D7_1449500 ·
AP2 domain transcription factor AP2-O5, putative
Audit flag: literature coverage
- Annotated
- 2026-09-08
44 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 44 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2014 | A transcriptional switch underlies commitment to sexual development in malaria parasites. | Nature | 397 | 24572369 |
| 2005 | Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. | Nucleic acids research | 395 | 16040597 |
| 2014 | A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. | Nature | 326 | 24572359 |
| 2014 | Heterochromatin protein 1 secures survival and transmission of malaria parasites. | Cell host & microbe | 217 | 25121746 |
| 2018 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. | Science (New York, N.Y.) | 195 | 29590075 |
| 2008 | Specific DNA-binding by apicomplexan AP2 transcription factors. | Proceedings of the National Academy of Sciences of the United States of America | 193 | 18541913 |
| 2014 | A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. | Cell host & microbe | 174 | 25121747 |
| 2017 | Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. | Nature | 168 | 29094698 |
| 2009 | Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. | Molecular microbiology | 164 | 19220746 |
| 2017 | A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. | Cell host & microbe | 163 | 28081440 |
| 2010 | The Apicomplexan AP2 family: integral factors regulating Plasmodium development. | Molecular and biochemical parasitology | 156 | 21126543 |
| 2018 | Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development. | Cell host & microbe | 140 | 29649445 |
| 2010 | A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. | PLoS pathogens | 134 | 20195509 |
| 2009 | Transcription factor AP2-Sp and its target genes in malarial sporozoites. | Molecular microbiology | 129 | 20025671 |
| 2017 | Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. | Cell host & microbe | 113 | 28618269 |
| 2020 | Dissecting the role of PfAP2-G in malaria gametocytogenesis. | Nature communications | 108 | 32198457 |
| 2018 | Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites. | Annual review of microbiology | 91 | 29975590 |
| 2018 | Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum. | Nature microbiology | 91 | 30478286 |
| 2012 | Identification of an AP2-family protein that is critical for malaria liver stage development. | PloS one | 88 | 23144823 |
| 2015 | Global transcriptional repression: An initial and essential step for Plasmodium sexual development. | Proceedings of the National Academy of Sciences of the United States of America | 84 | 26417110 |
| 2012 | A tetracycline-repressible transactivator system to study essential genes in malaria parasites. | Cell host & microbe | 76 | 23245327 |
| 2017 | Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. | Scientific reports | 74 | 28091569 |
| 2021 | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections. | Nature communications | 73 | 33903595 |
| 2020 | Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. | Science advances | 67 | 32577509 |
| 2017 | Systematic CRISPR-Cas9-Mediated Modifications of Plasmodium yoelii ApiAP2 Genes Reveal Functional Insights into Parasite Development. | mBio | 67 | 29233900 |
| 2018 | Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei. | Nature microbiology | 65 | 30177743 |
| 2020 | Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential. | Genome medicine | 63 | 31915075 |
| 2014 | Endoplasmic reticulum stress triggers gametocytogenesis in the malaria parasite. | The Journal of biological chemistry | 63 | 24755215 |
| 2016 | Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. | Scientific reports | 62 | 26813983 |
| 2019 | Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes. | Nature communications | 60 | 31086187 |
| 2017 | Adaptation of Plasmodium falciparum to its transmission environment. | Nature ecology & evolution | 59 | 29255304 |
| 2023 | Regulators of male and female sexual development are critical for the transmission of a malaria parasite. | Cell host & microbe | 58 | 36634679 |
| 2009 | Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator. | Journal of molecular biology | 57 | 19913037 |
| 2021 | A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. | Nucleic acids research | 49 | 34365503 |
| 2021 | A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures. | Nature microbiology | 48 | 34400833 |
| 2016 | Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia. | Proceedings of the National Academy of Sciences of the United States of America | 48 | 27911780 |
| 2010 | The construction and use of log-odds substitution scores for multiple sequence alignment. | PLoS computational biology | 48 | 20657661 |
| 2020 | From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium. | Frontiers in cellular and infection microbiology | 46 | 33425787 |
| 2021 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum. | PLoS pathogens | 44 | 34403450 |
| 2023 | Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation. | Nucleic acids research | 25 | 37026483 |
| 2022 | Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development. | PLoS pathogens | 22 | 35947628 |
| 2026 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | Nature communications | 0 | 42120403 |
| 2025 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | bioRxiv : the preprint server for biology | 0 | 41332573 |
| 2025 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | Research square | 0 | 41510253 |