AP2-EXP2
PF3D7_0611200 ·
AP2 domain transcription factor AP2-EXP2
Audit flag: literature coverage
- Annotated
- 2026-09-08
47 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 47 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2014 | A transcriptional switch underlies commitment to sexual development in malaria parasites. | Nature | 397 | 24572369 |
| 2005 | Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. | Nucleic acids research | 395 | 16040597 |
| 2009 | A newly discovered protein export machine in malaria parasites. | Nature | 381 | 19536257 |
| 2014 | A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. | Nature | 326 | 24572359 |
| 2014 | Heterochromatin protein 1 secures survival and transmission of malaria parasites. | Cell host & microbe | 217 | 25121746 |
| 2018 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. | Science (New York, N.Y.) | 195 | 29590075 |
| 2008 | Specific DNA-binding by apicomplexan AP2 transcription factors. | Proceedings of the National Academy of Sciences of the United States of America | 193 | 18541913 |
| 2012 | Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. | The Journal of clinical investigation | 187 | 22996664 |
| 2014 | A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. | Cell host & microbe | 174 | 25121747 |
| 2017 | Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. | Nature | 168 | 29094698 |
| 2009 | Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. | Molecular microbiology | 164 | 19220746 |
| 2017 | A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. | Cell host & microbe | 163 | 28081440 |
| 2018 | Malaria parasite translocon structure and mechanism of effector export. | Nature | 159 | 30150771 |
| 2010 | The Apicomplexan AP2 family: integral factors regulating Plasmodium development. | Molecular and biochemical parasitology | 156 | 21126543 |
| 2018 | Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development. | Cell host & microbe | 140 | 29649445 |
| 2010 | A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. | PLoS pathogens | 134 | 20195509 |
| 2009 | Transcription factor AP2-Sp and its target genes in malarial sporozoites. | Molecular microbiology | 129 | 20025671 |
| 2012 | Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). | The Journal of biological chemistry | 120 | 22253438 |
| 2017 | Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. | Cell host & microbe | 113 | 28618269 |
| 2020 | Dissecting the role of PfAP2-G in malaria gametocytogenesis. | Nature communications | 108 | 32198457 |
| 2018 | EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX. | Nature microbiology | 92 | 30150733 |
| 2018 | Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum. | Nature microbiology | 91 | 30478286 |
| 2016 | Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity. | PLoS pathogens | 76 | 27168322 |
| 2017 | Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. | Scientific reports | 74 | 28091569 |
| 2021 | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections. | Nature communications | 73 | 33903595 |
| 2013 | The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth. | Molecular microbiology | 72 | 23869529 |
| 2013 | Two putative protein export regulators promote Plasmodium blood stage development in vivo. | Molecular and biochemical parasitology | 66 | 24076174 |
| 2020 | Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential. | Genome medicine | 63 | 31915075 |
| 2016 | Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. | Scientific reports | 62 | 26813983 |
| 2019 | EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites. | PLoS biology | 61 | 31568532 |
| 2019 | Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes. | Nature communications | 60 | 31086187 |
| 2017 | Adaptation of Plasmodium falciparum to its transmission environment. | Nature ecology & evolution | 59 | 29255304 |
| 2019 | Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro. | Antimicrobial agents and chemotherapy | 58 | 31636063 |
| 2013 | Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking. | Malaria journal | 51 | 23561245 |
| 2010 | The construction and use of log-odds substitution scores for multiple sequence alignment. | PLoS computational biology | 48 | 20657661 |
| 2020 | From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium. | Frontiers in cellular and infection microbiology | 46 | 33425787 |
| 2017 | An ApiAP2 member regulates expression of clonally variant genes of the human malaria parasite Plasmodium falciparum. | Scientific reports | 43 | 29070841 |
| 2015 | The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine. | Antimicrobial agents and chemotherapy | 40 | 25691625 |
| 2015 | The Plasmodium berghei translocon of exported proteins reveals spatiotemporal dynamics of tubular extensions. | Scientific reports | 39 | 26219962 |
| 2015 | The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice. | Cellular microbiology | 36 | 26347246 |
| 2018 | Knockdown of the translocon protein EXP2 in Plasmodium falciparum reduces growth and protein export. | PloS one | 31 | 30439948 |
| 2018 | Spatial organization of protein export in malaria parasite blood stages. | Traffic (Copenhagen, Denmark) | 29 | 29696751 |
| 2020 | Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface. | Nature communications | 28 | 32732874 |
| 2018 | PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes. | Scientific reports | 28 | 29487358 |
| 1998 | Characterization and cloning of the gene encoding the vacuolar membrane protein EXP-2 from Plasmodium falciparum. | Molecular and biochemical parasitology | 28 | 9574909 |
| 2026 | Spatiotemporal dynamics of signal dependent exocytosis and parasitophorous vacuolar membrane rupture during Plasmodium falciparum egress. | PLoS pathogens | 1 | 42113900 |
| 2026 | A heterologous marker-free selection approach for CRISPR/Cas9-based gene editing in the malaria parasite Plasmodium falciparum. | mSphere | 0 | 41885428 |