{"gene":"PF3D7_0611200","run_date":"2026-09-08T12:51:26","timeline":{"discoveries":[],"current_model":"No mechanistic findings about PF3D7_0611200 (AP2-EXP2) are present in the available literature; none of the retrieved abstracts report experiments that directly characterize this specific ApiAP2 transcription factor's binding partners, target genes, enzymatic activity, structure, subcellular localization, or defined cellular role."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{},"corpus_meta":[{"pmid":"24572369","id":"PMC_24572369","title":"A transcriptional switch underlies commitment to sexual development in malaria 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communications","url":"https://pubmed.ncbi.nlm.nih.gov/32732874","citation_count":28,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"9574909","id":"PMC_9574909","title":"Characterization and cloning of the gene encoding the vacuolar membrane protein EXP-2 from Plasmodium falciparum.","date":"1998","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/9574909","citation_count":28,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"29487358","id":"PMC_29487358","title":"PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes.","date":"2018","source":"Scientific 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falciparum.","date":"2026","source":"mSphere","url":"https://pubmed.ncbi.nlm.nih.gov/41885428","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["PfAP2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":24683,"output_tokens":448,"usd":0.040384,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.040384,"stage1_batch_id":"msgbatch_01DisAaTypwmC8QwdMBuePHo","stage2_batch_id":"msgbatch_0184zxZTqxiEfdYYfPMfkqjb","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking through the abstracts, I need to identify papers about PF3D7_0611200 (AP2-EXP2). \n\nFirst, let me clarify what this gene is. PF3D7_0611200 is annotated as \"AP2 domain transcription factor AP2-EXP2.\" I need to be careful here — many papers in this corpus are about EXP2 (the PTEX translocon component, a different protein), about AP2-G (the sexual commitment master regulator), about AP2-exp (PF3D7_1466400), or about other ApiAP2 family members. These are all distinct genes.\n\nSearching through the abstracts for specific mentions of PF3D7_0611200 or \"AP2-EXP2\" as a transcription factor... None of the abstracts explicitly mention \"AP2-EXP2\" or \"PF3D7_0611200\" by those identifiers. \n\nPaper [37] mentions \"AP2-exp (PF3D7_1466400)\" — this is a different gene (PF3D7_1466400), not PF3D7_0611200.\n\nPaper [10] mentions \"other AP2 transcription factors\" upregulated in committed schizonts but doesn't name PF3D7_0611200 specifically.\n\nNone of the abstracts contain mechanistic findings specifically about PF3D7_0611200 (AP2-EXP2).\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about PF3D7_0611200 (AP2-EXP2) are present in the available literature; none of the retrieved abstracts report experiments that directly characterize this specific ApiAP2 transcription factor's binding partners, target genes, enzymatic activity, structure, subcellular localization, or defined cellular role.\"\n}\n```","stage2_raw":"","audit_flag":{"gene":"PF3D7_0611200","tier":"COVERAGE","verdict":"Coverage note","subtype":"corpus_generic","uniprot_band":"empty","rules_fired":"R1","issue":"R1: gene named in 0/100 (0%) of its corpus abstracts and Stage 1 extracted no discoveries — no gene-specific literature retrieved"},"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_0611200","name":null,"product":"AP2 domain transcription factor AP2-EXP2","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_0109500","name":null,"product":"AP2 domain transcription factor, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1139200","name":null,"product":"AP2 domain transcription factor AP2-EXP2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"AP2-EXP2","evaluation":null}