COX6C

COX6C (PF3D7_0306500) is a component of the mitochondrial respiratory chain complex IV (cytochrome c oxidase) in Plasmodium falciparum, identified through complexome profiling that mapped its co-migration with the assembled complex across asexual blood stages and gametocytes (PMID:34155201). The available corpus establishes only this membership in complex IV; beyond its assignment to the cytochrome c oxidase complex (PMID:34155201), no further mechanistic detail — molecular activity, assembly role, or stage-specific function specific to PF3D7_0306500 — has been characterized.

1. 2021 Medium

   Whether PF3D7_0306500 participates in the P. falciparum respiratory chain was unknown; complexome profiling answered this by placing it within assembled complex IV, establishing its membership in the mitochondrial cytochrome c oxidase.

   Evidence Complexome profiling (co-migration/mass spectrometry-based complex mapping) across asexual blood and gametocyte stages in P. falciparum

   PMID:34155201

   Open questions at the time

   • No mutagenesis or reconstitution to define the functional contribution of PF3D7_0306500 to complex IV activity
   • Molecular activity and structural placement of the subunit within the complex not resolved
   • Stage-specific dependence and essentiality of this individual subunit not tested

• The specific function, essentiality, and mechanistic contribution of PF3D7_0306500 to cytochrome c oxidase assembly or activity remain undefined in the available corpus.
• No genetic knockout or knockdown phenotype for PF3D7_0306500
• No biochemical assay isolating its role in electron transfer or complex assembly
• No structural model localizing the subunit within complex IV