Affinage · Plasmodium

RPL37A

PF3D7_0210100 · 60S ribosomal protein L37ae, putative

Audit flag: identity unverified
Annotated
2026-09-07
3 papers in source corpus 2 papers cited in narrative 2 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PF3D7_0210100 (RPL37A) is a structural component of the 60S large subunit of the Plasmodium falciparum 80S cytoplasmic ribosome, placed within the large-subunit architecture by high-resolution cryo-EM structures of the intact translation-competent ribosome (PMID:24913268, PMID:26432834). Its assignment is based on structural membership in the assembled ribosome purified from blood-stage schizonts rather than on any experiment probing RPL37A individually (PMID:26432834). Beyond this membership in the ribosomal large subunit, no experiment in the available corpus has probed the individual function, binding partners, or enzymatic activity of PF3D7_0210100.

Mechanistic history

Synthesis pass · year-by-year structured walk · 2 steps
  1. 2014 Medium

    Whether PF3D7_0210100 is part of the assembled P. falciparum ribosome was resolved by placing it structurally within the machine.

    Evidence Cryo-EM structure of the intact P. falciparum 80S ribosome at 3.2 Å resolution assigning RPL37A to the 60S large subunit

    PMID:24913268

    Open questions at the time
    • No experiment probes RPL37A function, interactions, or essentiality individually
    • Role in ribosome assembly or translation activity not tested
    • Position within the subunit inferred from whole-ribosome structure, not isolated study
  2. 2015 Medium

    Whether RPL37A is a stable component of the native, translation-competent ribosome was confirmed using ribosomes isolated from parasites rather than reconstituted material.

    Evidence Cryo-EM reconstructions with flexible-fitting atomic model building from schizont-purified P. falciparum 80S ribosomes place RPL37A within the 60S subunit

    PMID:26432834

    Open questions at the time
    • Does not interrogate RPL37A-specific contacts or contributions to subunit function
    • No functional perturbation (knockdown/knockout) performed
    • Any parasite-specific role distinct from the general structural role remains untested

Open questions

Synthesis pass · forward-looking unresolved questions
  • The individual function, binding partners, essentiality, and any parasite-specific role of PF3D7_0210100 beyond structural membership in the 60S subunit remain uncharacterized.
  • No functional or genetic study of RPL37A
  • No defined interaction partners beyond co-membership in the large subunit
  • No structural or mechanistic feature distinguishing it from a generic ribosomal protein

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
60S large ribosomal subunit80S cytoplasmic ribosome

Evidence

Reading pass · 2 per-paper findings extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2014 Cryo-EM structure of the P. falciparum 80S ribosome at 3.2 Å resolution places RPL37A (PF3D7_0210100) as a component of the 60S large subunit within the assembled 80S ribosome complex. Cryo-EM structure determination at 3.2 Å resolution of the intact P. falciparum 80S ribosome eLife Medium 24913268
2015 Cryo-EM reconstructions of the P. falciparum 80S ribosome purified from blood-stage schizonts confirm RPL37A (PF3D7_0210100) as a structural component of the 60S subunit in the assembled translation-competent ribosome, and atomic models built by flexible fitting place it within the large subunit architecture. Cryo-EM with sub-nanometer resolution reconstructions and flexible-fitting atomic model building from schizont-purified ribosomes Nucleic acids research Medium 26432834

Source papers

Stage 0 corpus · 3 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2014 Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine. eLife 276 24913268
2017 Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nature microbiology 138 28288098
2015 Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic acids research 46 26432834