PF3D7_0809500

PF3D7_0809500 (NuA4) is a subunit of the Plasmodium falciparum NuA4-like histone acetyltransferase complex (PfNuA4), which contains 11 of the 13 conserved NuA4 subunits and shares the PfEAF2 component with the SWR1 complex (PMID:38564734). Its membership in this complex was established by reciprocal co-immunoprecipitation and pulldown with mass spectrometry (PMID:38564734). Beyond (PMID:38564734), no further mechanistic detail specific to PF3D7_0809500 — its individual biochemical activity, structural contribution, or dedicated function within the complex — has been characterized in the available corpus.

1. 2024 Medium

   It was unknown whether P. falciparum assembles a NuA4-like histone acetyltransferase complex and which parasite proteins compose it; identifying PF3D7_0809500 as a component placed this gene within a defined chromatin-modifying machine.

   Evidence reciprocal co-immunoprecipitation/pulldown with mass spectrometry, using the shared NuA4/SWR1 component PfEAF2 as bait, in P. falciparum

   PMID:38564734

   Open questions at the time

   • The specific molecular activity or structural role of PF3D7_0809500 within PfNuA4 is not resolved.
   • Complex membership rests on a single lab and a single primary method (co-IP/pulldown) without independent replication or orthogonal structural validation.
   • Substrate specificity, genomic targeting, and functional consequences attributable to PF3D7_0809500 itself are not addressed.

• What PF3D7_0809500 contributes to PfNuA4 beyond being a structural subunit — its individual biochemical function, essentiality, and role in histone acetylation-driven gene regulation — remains unestablished.
• No knockdown/knockout phenotype specific to PF3D7_0809500 reported.
• No demonstration of catalytic or scaffolding function for this subunit.
• No genome-wide occupancy or target-gene data for this subunit.