Affinage · Plasmodium

PF3D7_0807500

proteasome subunit alpha type-6, putative

Annotated
2026-09-08
7 papers in source corpus 1 papers cited in narrative 1 extracted findings

Mechanistic narrative

Synthesis pass · prose summary of the discoveries below

PF3D7_0807500 (proteasome subunit alpha type-6, putative) is a structural component of the P. falciparum 20S proteasome (Pf20S), a proteolytic complex whose overall architecture was resolved by cryo-EM to 3.6 Å (PMID:26863983). Beyond its membership in this complex, no experiment in the available corpus establishes a specific individual function or mechanism for the alpha-6 subunit; its role is inferred solely from its participation in the 20S proteasome (PMID:26863983).

Mechanistic history

Synthesis pass · year-by-year structured walk · 1 step
  1. 2016 Low

    Placing PF3D7_0807500 within the P. falciparum 20S proteasome established it as a structural subunit of an essential proteolytic machine, but did not resolve any function unique to this subunit.

    Evidence Cryo-electron microscopy and single-particle analysis of the Pf20S proteasome complex

    PMID:26863983

    Open questions at the time
    • No experiment interrogates PF3D7_0807500 individually; membership is inferred only from the whole-complex structure
    • No subunit-specific catalytic, assembly, or regulatory role has been defined
    • No genetic or biochemical perturbation of this subunit has been reported

Open questions

Synthesis pass · forward-looking unresolved questions
  • Whether PF3D7_0807500 contributes any function beyond structural membership in the 20S proteasome remains unknown.
  • No individual functional characterization of the alpha-6 subunit exists in the available corpus
  • Its specific contribution to Pf20S assembly, stability, or substrate handling is undefined

Mechanism profile

Synthesis pass · controlled-vocabulary classification
Complex memberships
P. falciparum 20S proteasome (Pf20S) [#0]

Evidence

Reading pass · 1 per-paper finding extracted from the source corpus
Year Finding Method Journal Conf PMIDs
2016 PF3D7_0807500 (proteasome subunit alpha type-6) is a structural component of the P. falciparum 20S proteasome (Pf20S), whose overall architecture was resolved by cryo-EM to 3.6 Å. No findings specific to the alpha-6 subunit's individual function or mechanism were reported; the subunit's role is inferred solely from its membership in the 20S complex. Cryo-electron microscopy and single-particle analysis of the Pf20S proteasome complex Nature Low 26863983

Source papers

Stage 0 corpus · 7 papers · ranked by NIH iCite citations
Year Title Journal Citations PMID
2016 Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature 196 26863983
2012 The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention? International journal for parasitology. Drugs and drug resistance 64 24533266
2019 The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nature microbiology 37 31384003
2021 Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America 33 34548400
2023 Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors. Nature communications 21 38097652
2024 Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria. Cell chemical biology 11 39084225
2025 Optimization of Species-Selective Reversible Proteasome Inhibitors for the Treatment of Malaria. Journal of medicinal chemistry 1 41148577