PF3D7_0420300
AP2 domain transcription factor, putative
Audit flag: literature coverage
- Annotated
- 2026-09-07
91 papers in source corpus
Mechanistic narrative
Synthesis pass · prose summary of the discoveries below
No mechanistic discoveries found in literature.
Mechanism profile
Synthesis pass · controlled-vocabulary classification
No controlled-vocabulary terms were assigned to this entry.
Source papers
Stage 0 corpus · 91 papers · ranked by NIH iCite citations
| Year | Title | Journal | Citations | PMID |
|---|---|---|---|---|
| 2014 | A transcriptional switch underlies commitment to sexual development in malaria parasites. | Nature | 395 | 24572369 |
| 2005 | Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains. | Nucleic acids research | 393 | 16040597 |
| 2014 | A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium. | Nature | 325 | 24572359 |
| 2014 | Heterochromatin protein 1 secures survival and transmission of malaria parasites. | Cell host & microbe | 216 | 25121746 |
| 2018 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. | Science (New York, N.Y.) | 192 | 29590075 |
| 2008 | Specific DNA-binding by apicomplexan AP2 transcription factors. | Proceedings of the National Academy of Sciences of the United States of America | 191 | 18541913 |
| 2014 | A Plasmodium falciparum histone deacetylase regulates antigenic variation and gametocyte conversion. | Cell host & microbe | 174 | 25121747 |
| 2017 | Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites. | Nature | 167 | 29094698 |
| 2009 | Identification of a transcription factor in the mosquito-invasive stage of malaria parasites. | Molecular microbiology | 163 | 19220746 |
| 2017 | A Knockout Screen of ApiAP2 Genes Reveals Networks of Interacting Transcriptional Regulators Controlling the Plasmodium Life Cycle. | Cell host & microbe | 160 | 28081440 |
| 2010 | The Apicomplexan AP2 family: integral factors regulating Plasmodium development. | Molecular and biochemical parasitology | 156 | 21126543 |
| 2018 | Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development. | Cell host & microbe | 137 | 29649445 |
| 2010 | A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. | PLoS pathogens | 134 | 20195509 |
| 2009 | Transcription factor AP2-Sp and its target genes in malarial sporozoites. | Molecular microbiology | 128 | 20025671 |
| 2017 | Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-I Transcription Factor. | Cell host & microbe | 112 | 28618269 |
| 2020 | Dissecting the role of PfAP2-G in malaria gametocytogenesis. | Nature communications | 108 | 32198457 |
| 2018 | Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites. | Annual review of microbiology | 91 | 29975590 |
| 2018 | Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum. | Nature microbiology | 89 | 30478286 |
| 2012 | Identification of an AP2-family protein that is critical for malaria liver stage development. | PloS one | 87 | 23144823 |
| 2015 | Global transcriptional repression: An initial and essential step for Plasmodium sexual development. | Proceedings of the National Academy of Sciences of the United States of America | 84 | 26417110 |
| 2012 | A tetracycline-repressible transactivator system to study essential genes in malaria parasites. | Cell host & microbe | 76 | 23245327 |
| 2017 | Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae. | Scientific reports | 74 | 28091569 |
| 2021 | Higher gametocyte production and mosquito infectivity in chronic compared to incident Plasmodium falciparum infections. | Nature communications | 71 | 33903595 |
| 2020 | Conditional expression of PfAP2-G for controlled massive sexual conversion in Plasmodium falciparum. | Science advances | 65 | 32577509 |
| 2018 | Inducible developmental reprogramming redefines commitment to sexual development in the malaria parasite Plasmodium berghei. | Nature microbiology | 65 | 30177743 |
| 2020 | Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential. | Genome medicine | 62 | 31915075 |
| 2016 | Proteome-wide analysis reveals widespread lysine acetylation of major protein complexes in the malaria parasite. | Scientific reports | 62 | 26813983 |
| 2014 | Endoplasmic reticulum stress triggers gametocytogenesis in the malaria parasite. | The Journal of biological chemistry | 61 | 24755215 |
| 2019 | Plasmodium falciparum sexual differentiation in malaria patients is associated with host factors and GDV1-dependent genes. | Nature communications | 60 | 31086187 |
| 2017 | Adaptation of Plasmodium falciparum to its transmission environment. | Nature ecology & evolution | 59 | 29255304 |
| 2019 | Modification of pfap2μ and pfubp1 Markedly Reduces Ring-Stage Susceptibility of Plasmodium falciparum to Artemisinin In Vitro. | Antimicrobial agents and chemotherapy | 57 | 31636063 |
| 2009 | Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator. | Journal of molecular biology | 57 | 19913037 |
| 2023 | Regulators of male and female sexual development are critical for the transmission of a malaria parasite. | Cell host & microbe | 53 | 36634679 |
| 2013 | Artemisinin resistance in rodent malaria--mutation in the AP2 adaptor μ-chain suggests involvement of endocytosis and membrane protein trafficking. | Malaria journal | 50 | 23561245 |
| 2021 | A cascade of transcriptional repression determines sexual commitment and development in Plasmodium falciparum. | Nucleic acids research | 49 | 34365503 |
| 2010 | The construction and use of log-odds substitution scores for multiple sequence alignment. | PLoS computational biology | 48 | 20657661 |
| 2016 | Selective sweep suggests transcriptional regulation may underlie Plasmodium vivax resilience to malaria control measures in Cambodia. | Proceedings of the National Academy of Sciences of the United States of America | 46 | 27911780 |
| 2015 | Specific expression and export of the Plasmodium falciparum Gametocyte EXported Protein-5 marks the gametocyte ring stage. | Malaria journal | 46 | 26315106 |
| 2021 | A heat-shock response regulated by the PfAP2-HS transcription factor protects human malaria parasites from febrile temperatures. | Nature microbiology | 45 | 34400833 |
| 2021 | The PfAP2-G2 transcription factor is a critical regulator of gametocyte maturation. | Molecular microbiology | 44 | 33368818 |
| 2020 | From Genes to Transcripts, a Tightly Regulated Journey in Plasmodium. | Frontiers in cellular and infection microbiology | 43 | 33425787 |
| 2021 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion and virulence in the malaria parasite Plasmodium falciparum. | PLoS pathogens | 42 | 34403450 |
| 2019 | Female-specific gene regulation in malaria parasites by an AP2-family transcription factor. | Molecular microbiology | 42 | 31231888 |
| 2023 | Sexual differentiation in human malaria parasites is regulated by competition between phospholipid metabolism and histone methylation. | Nature microbiology | 41 | 37277533 |
| 2017 | Capturing in vivo RNA transcriptional dynamics from the malaria parasite Plasmodium falciparum. | Genome research | 39 | 28416533 |
| 2020 | Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences. | Epigenetics & chromatin | 34 | 33225957 |
| 2017 | PfAP2Tel, harbouring a non-canonical DNA-binding AP2 domain, binds to Plasmodium falciparum telomeres. | Cellular microbiology | 31 | 28376558 |
| 2023 | DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages. | Nature microbiology | 30 | 37884813 |
| 2021 | Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes. | EMBO reports | 29 | 33665945 |
| 2021 | Mechanisms of triggering malaria gametocytogenesis by AP2-G. | Parasitology international | 28 | 34119684 |
| 2023 | Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment. | eLife | 27 | 36916164 |
| 2021 | The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite Plasmodium falciparum. | iScience | 27 | 33997710 |
| 2020 | Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites. | mBio | 26 | 32487761 |
| 2020 | Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases. | ACS infectious diseases | 25 | 32272012 |
| 2010 | From cradle to grave: RNA biology in malaria parasites. | Wiley interdisciplinary reviews. RNA | 25 | 21935891 |
| 2019 | The role of epigenetics and chromatin structure in transcriptional regulation in malaria parasites. | Briefings in functional genomics | 24 | 31220857 |
| 2017 | A disrupted transsulphuration pathway results in accumulation of redox metabolites and induction of gametocytogenesis in malaria. | Scientific reports | 24 | 28091526 |
| 2023 | Characterization of the dual role of Plasmodium falciparum DNA methyltransferase in regulating transcription and translation. | Nucleic acids research | 23 | 37026483 |
| 2019 | A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum. | Cellular microbiology | 23 | 31734953 |
| 2021 | A Randomized Clinical Trial to Compare Plasmodium falciparum Gametocytemia and Infectivity After Blood-Stage or Mosquito Bite-Induced Controlled Malaria Infection. | The Journal of infectious diseases | 22 | 32239171 |
| 2021 | Single-Cell RNA Sequencing Reveals Cellular Heterogeneity and Stage Transition under Temperature Stress in Synchronized Plasmodium falciparum Cells. | Microbiology spectrum | 22 | 34232098 |
| 2022 | A Dynamic and Combinatorial Histone Code Drives Malaria Parasite Asexual and Sexual Development. | Molecular & cellular proteomics : MCP | 21 | 35051657 |
| 2022 | Identification of a novel AP2 transcription factor in zygotes with an essential role in Plasmodium ookinete development. | PLoS pathogens | 21 | 35947628 |
| 2019 | Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features. | PLoS computational biology | 20 | 31509524 |
| 2023 | In silico Structure Prediction, Molecular Docking, and Dynamic Simulation of Plasmodium falciparum AP2-I Transcription Factor. | Bioinformatics and biology insights | 18 | 36704725 |
| 2022 | Inhibitors of ApiAP2 protein DNA binding exhibit multistage activity against Plasmodium parasites. | PLoS pathogens | 18 | 36223427 |
| 2020 | Metabolic regulation of sexual commitment in Plasmodium falciparum. | Current opinion in microbiology | 17 | 33053503 |
| 2016 | Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines. | Malaria journal | 17 | 27098483 |
| 2021 | A 39-Amino-Acid C-Terminal Truncation of GDV1 Disrupts Sexual Commitment in Plasmodium falciparum. | mSphere | 16 | 34011691 |
| 2022 | Plasmodium falciparum Sexual Commitment Rate Variation among Clinical Isolates and Diverse Laboratory-Adapted Lines. | Microbiology spectrum | 15 | 36409095 |
| 2021 | H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum. | Epigenetics & chromatin | 15 | 33794978 |
| 2021 | PfAP2-G2 Is Associated to Production and Maturation of Gametocytes in Plasmodium falciparum via Regulating the Expression of PfMDV-1. | Frontiers in microbiology | 14 | 33537025 |
| 2024 | DNA sequence and chromatin differentiate sequence-specific transcription factor binding in the human malaria parasite Plasmodium falciparum. | Nucleic acids research | 13 | 38966997 |
| 2025 | SIP2 is the master transcription factor of Plasmodium merozoite formation. | Science advances | 6 | 40117352 |
| 2025 | High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes. | Nature microbiology | 5 | 40588593 |
| 2025 | Pink or blue: sex determination in malaria gametocytes. | Trends in parasitology | 2 | 41107154 |
| 2025 | Transcription factor 25 modulates gametocytogenesis and ribosome biogenesis in the malaria parasite Plasmodium falciparum. | Frontiers in cellular and infection microbiology | 2 | 41210950 |
| 2025 | Structural characterization of the ACDC domain from ApiAP2 proteins, a potential molecular target against apicomplexan parasites. | Acta crystallographica. Section D, Structural biology | 1 | 39820027 |
| 2025 | Plasmodium falciparum transcription factor AP2-06B is mutated at high frequency in Southeast Asia but does not associate with drug resistance. | Frontiers in cellular and infection microbiology | 1 | 39835275 |
| 2025 | Heterochromatin de novo formation and maintenance in Plasmodium falciparum. | PLoS pathogens | 1 | 40455742 |
| 2026 | Precise gene regulation through transcriptional repression is essential for Plasmodium berghei asexual blood stage development. | Nature communications | 0 | 41484140 |
| 2026 | A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation. | Nature communications | 0 | 41547993 |
| 2026 | Molecular mechanisms involved in Plasmodium gametocytogenesis. | Frontiers in microbiology | 0 | 41716278 |
| 2026 | A heterologous marker-free selection approach for CRISPR/Cas9-based gene editing in the malaria parasite Plasmodium falciparum. | mSphere | 0 | 41885428 |
| 2026 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | Nature communications | 0 | 42120403 |
| 2026 | The DNA-binding protein PfAP2-V regulates erythrocyte invasion and pathogenesis of the human malaria parasite Plasmodium falciparum. | Science China. Life sciences | 0 | 42258137 |
| 2025 | GCN5 Is a Master Regulator of Gene Expression in the Malaria Parasite Plasmodium falciparum. | Cells | 0 | 40558503 |
| 2025 | A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation. | bioRxiv : the preprint server for biology | 0 | 40568120 |
| 2025 | An ApiAP2 Family Transcriptional Factor PfAP2-06B Regulates Erythrocyte Invasion Indirectly in Plasmodium falciparum. | Pathogens (Basel, Switzerland) | 0 | 41305314 |
| 2025 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | bioRxiv : the preprint server for biology | 0 | 41332573 |
| 2025 | A divergent Plasmodium NEK4 acts as a key regulator driving the early events of meiosis. | Research square | 0 | 41510253 |