{"gene":"PF3D7_1448200","run_date":"2026-09-08T14:19:07","timeline":{"discoveries":[{"year":2020,"finding":"PF3D7_1448200 (CAPG2), as a condensin-2 complex subunit, forms part of condensin II complexes in P. falciparum during mature schizogony and male gametogenesis, but condensin II complexes do not form during early schizogony when SMC2/SMC4 are restricted to centromeres.","method":"Co-immunoprecipitation and fluorescence localization studies of condensin complex subunits across parasite life cycle stages","journal":"Cell reports","confidence":"Low","confidence_rationale":"Tier 3 / Weak — CAPG2 is only mentioned as part of the condensin II complex; no direct experiment specifically interrogates CAPG2/PF3D7_1448200 function or localization independently; findings are primarily about SMC2/SMC4 core subunits","pmids":["32049018"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"current_model":"PF3D7_1448200 (CAPG2) is established only as a member of the condensin II complex in P. falciparum, with complex formation occurring during mature schizogony and male gametogenesis but not during early schizogony; no direct mechanistic experiments have been performed on CAPG2 itself."},"narrative":{"mechanistic_narrative":"PF3D7_1448200 (CAPG2) is characterized in the available corpus only as a subunit of the condensin II complex in Plasmodium falciparum, where it forms part of assembled condensin II complexes during mature schizogony and male gametogenesis but not during early schizogony, a stage at which the SMC2/SMC4 core subunits are restricted to centromeres [PMID:32049018]. No direct experiment has interrogated the function, localization, or interactions of CAPG2 itself independently of the broader condensin II complex, and beyond its stage-restricted complex membership [PMID:32049018] no further mechanistic detail has been characterized in the available corpus.","teleology":[{"year":2020,"claim":"To place CAPG2 in a cellular context, it was asked whether this subunit participates in condensin II assembly and when across the parasite life cycle; the work established that CAPG2 is present in condensin II complexes specifically during mature schizogony and male gametogenesis, and not during early schizogony.","evidence":"Co-immunoprecipitation and fluorescence localization of condensin subunits across P. falciparum life cycle stages","pmids":["32049018"],"confidence":"Low","gaps":["CAPG2 was only detected as part of the condensin II complex; no experiment directly interrogated CAPG2/PF3D7_1448200 function or localization independently","findings center on the SMC2/SMC4 core subunits rather than CAPG2 itself","the specific contribution of CAPG2 to complex assembly, chromosome condensation, or stage-specific regulation is undefined"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":null,"claim":"It remains unknown what CAPG2 contributes mechanistically to condensin II function, whether it has any activity or localization separable from the complex, and how its incorporation is regulated across life cycle stages.","evidence":"","pmids":[],"confidence":"Low","gaps":["no direct loss-of-function or biochemical characterization of CAPG2","no structural or domain-level analysis of CAPG2 within condensin II","no defined phenotype attributable specifically to CAPG2"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["condensin II complex"],"partners":[],"other_free_text":["CAPG2 is present in condensin II complexes during mature schizogony and male gametogenesis, but complexes do not form during early schizogony [#0]","No direct mechanistic experiment on CAPG2/PF3D7_1448200 has been performed; it is established only as a condensin II complex member [#0]"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"32049018","id":"PMC_32049018","title":"Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.","date":"2020","source":"Cell reports","url":"https://pubmed.ncbi.nlm.nih.gov/32049018","citation_count":30,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["curated_ref"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":3322,"output_tokens":391,"usd":0.007916,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":4864,"output_tokens":1060,"usd":0.02541,"stage2_stop_reason":"end_turn"},"total_usd":0.033326,"stage1_batch_id":"msgbatch_011BPjN2BL33F8cJXD1r7V7T","stage2_batch_id":"msgbatch_01Qwg6vP7qxkpL6Gsc7tajsb","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2020,\n      \"finding\": \"PF3D7_1448200 (CAPG2), as a condensin-2 complex subunit, forms part of condensin II complexes in P. falciparum during mature schizogony and male gametogenesis, but condensin II complexes do not form during early schizogony when SMC2/SMC4 are restricted to centromeres.\",\n      \"method\": \"Co-immunoprecipitation and fluorescence localization studies of condensin complex subunits across parasite life cycle stages\",\n      \"journal\": \"Cell reports\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — CAPG2 is only mentioned as part of the condensin II complex; no direct experiment specifically interrogates CAPG2/PF3D7_1448200 function or localization independently; findings are primarily about SMC2/SMC4 core subunits\",\n      \"pmids\": [\"32049018\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}\n      ]\n    }\n  ],\n  \"current_model\": \"PF3D7_1448200 (CAPG2) is established only as a member of the condensin II complex in P. falciparum, with complex formation occurring during mature schizogony and male gametogenesis but not during early schizogony; no direct mechanistic experiments have been performed on CAPG2 itself.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"PF3D7_1448200 (CAPG2) is characterized in the available corpus only as a subunit of the condensin II complex in Plasmodium falciparum, where it forms part of assembled condensin II complexes during mature schizogony and male gametogenesis but not during early schizogony, a stage at which the SMC2/SMC4 core subunits are restricted to centromeres [#0]. No direct experiment has interrogated the function, localization, or interactions of CAPG2 itself independently of the broader condensin II complex, and beyond its stage-restricted complex membership [#0] no further mechanistic detail has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2020,\n      \"claim\": \"To place CAPG2 in a cellular context, it was asked whether this subunit participates in condensin II assembly and when across the parasite life cycle; the work established that CAPG2 is present in condensin II complexes specifically during mature schizogony and male gametogenesis, and not during early schizogony.\",\n      \"evidence\": \"Co-immunoprecipitation and fluorescence localization of condensin subunits across P. falciparum life cycle stages\",\n      \"pmids\": [\"32049018\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"CAPG2 was only detected as part of the condensin II complex; no experiment directly interrogated CAPG2/PF3D7_1448200 function or localization independently\",\n        \"findings center on the SMC2/SMC4 core subunits rather than CAPG2 itself\",\n        \"the specific contribution of CAPG2 to complex assembly, chromosome condensation, or stage-specific regulation is undefined\"\n      ],\n      \"attribution\": [\n        {\n          \"species\": \"Plasmodium falciparum\",\n          \"strain\": \"\"\n        }\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"It remains unknown what CAPG2 contributes mechanistically to condensin II function, whether it has any activity or localization separable from the complex, and how its incorporation is regulated across life cycle stages.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"no direct loss-of-function or biochemical characterization of CAPG2\",\n        \"no structural or domain-level analysis of CAPG2 within condensin II\",\n        \"no defined phenotype attributable specifically to CAPG2\"\n      ],\n      \"attribution\": [\n        {\n          \"species\": \"Plasmodium falciparum\",\n          \"strain\": \"\"\n        }\n      ]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [],\n    \"pathway\": [],\n    \"complexes\": [\"condensin II complex\"],\n    \"partners\": [],\n    \"other_free_text\": [\n      \"CAPG2 is present in condensin II complexes during mature schizogony and male gametogenesis, but complexes do not form during early schizogony [#0]\",\n      \"No direct mechanistic experiment on CAPG2/PF3D7_1448200 has been performed; it is established only as a condensin II complex member [#0]\"\n    ]\n  }\n}","audit_flag":{"gene":"PF3D7_1448200","tier":"IDENTITY_CHECK","verdict":"identity unverified","subtype":"names_other_cards","uniprot_band":"","rules_fired":"R12","issue":"No cited paper names this card; 1 of 1 cited papers name other catalogue genes (PF3D7_0509100, PF3D7_0616200, PF3D7_1318400). The summary may describe one of those genes."},"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1448200","name":null,"product":"condensin-2 complex subunit G2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_1312000","name":null,"product":"condensin-2 complex subunit G2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1233900","name":null,"product":"condensin-2 complex subunit G2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"CAPG2","evaluation":null}