{"gene":"PF3D7_1409800","run_date":"2026-09-08T19:44:17","timeline":{"discoveries":[{"year":2014,"finding":"CELF2 (PfCELF2) was tested for RNA binding activity using UV-crosslinking and electrophoretic mobility shift assays and was found to be negative for RNA binding activity, in contrast to its paralog PfCELF1 which did bind RNA.","method":"UV-crosslinking assay and electrophoretic mobility shift assay (EMSA)","journal":"Molecular and biochemical parasitology","confidence":"Medium","confidence_rationale":"Tier 1 / Weak — direct in vitro biochemical assays (UV-crosslinking and EMSA) but single lab, single study; result is a negative finding","pmids":["25447287"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2014,"finding":"RNA immunoprecipitation-microarray (ribonomics) analysis found that CELF2 (PfCELF2) bound to only 26 features from 22 mRNAs, indicating very few or no biologically relevant mRNA targets in asexual stages, in contrast to PfCELF1 which bound 1376 features from 1040 mRNAs.","method":"RNA immunoprecipitation coupled to DNA microarray (ribonomics)","journal":"Molecular and biochemical parasitology","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — immunoprecipitation-based mRNA target identification, single lab, single study; interpreted as a near-negative result","pmids":["25447287"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2019,"finding":"CELF2 (as CELF2/Bruno) was identified as a component of the CAF1/CCR4/NOT complex in Plasmodium yoelii through mass spectrometric analysis of immunoprecipitated PyCCR4-1::GFP, placing CELF2 in a complex with CAF1, NOT1, DOZI, CITH, and PABP that is associated with translational repression.","method":"Co-immunoprecipitation via GFP-trap followed by mass spectrometry (SAINT analysis)","journal":"PLoS pathogens","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — reciprocal IP-MS with SAINT scoring, single lab, single study","pmids":["30703164"],"is_preprint":false,"attribution":[{"species":"Plasmodium yoelii","strain":""}]},{"year":2024,"finding":"CELF2 was identified as a component of PfDOZI-associated mRNPs in both schizonts (processing body-like mRNPs) and gametocytes (germ cell granule-like mRNPs) of P. falciparum, by immunoprecipitation of PfDOZI::GFP followed by mass spectrometry, indicating CELF2 participates in distinct mRNA regulatory complexes across life stages.","method":"Co-immunoprecipitation (GFP-trap) coupled to mass spectrometry","journal":"Nature communications","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — IP-MS in two parasite stages, single lab; establishes complex membership but no direct functional assay of CELF2 itself","pmids":["38702310"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2025,"finding":"CELF2 was identified as a stage-independent interactor of DOZI (present in both female gametocytes and zygotes) by TurboID-based proximity proteomics in P. yoelii, while CELF2 was also found as a stage-dependent interactor of ALBA4 in gametocytes (but not in zygotes), suggesting CELF2 participates in the DOZI/CITH/ALBA translational repression complex.","method":"TurboID-based proximity proteomics (proximity labeling followed by mass spectrometry)","journal":"PLoS pathogens","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — proximity proteomics with quantitative comparison across two life stages, single lab, single study","pmids":["39777415"],"is_preprint":false,"attribution":[{"species":"Plasmodium yoelii","strain":""}]}],"current_model":"CELF2 (PF3D7_1409800) in P. falciparum lacks detectable RNA-binding activity in asexual stages by direct biochemical assay, yet is a constituent of the DOZI/CITH/ALBA translational repression complex and the CAF1/CCR4/NOT complex — associations demonstrated by co-immunoprecipitation and proximity proteomics in both P. falciparum and P. yoelii across asexual, gametocyte, and zygote stages — indicating its role is mediated through complex membership rather than autonomous RNA binding."},"narrative":{"mechanistic_narrative":"CELF2 (PF3D7_1409800) is a constituent of Plasmodium translational repression machinery that operates through complex membership rather than autonomous RNA engagement. In P. falciparum asexual stages, direct in vitro assays established that CELF2 lacks detectable RNA-binding activity and captures only a negligible set of mRNAs, in sharp contrast to its paralog PfCELF1 [PMID:25447287]. Despite this absence of intrinsic RNA binding, CELF2 is repeatedly recovered as a component of mRNP repression complexes: in P. yoelii it co-purifies with the CAF1/CCR4/NOT deadenylase complex alongside CAF1, NOT1, DOZI, CITH and PABP [PMID:30703164], and in P. falciparum it is found in PfDOZI-associated mRNPs that resemble processing bodies in schizonts and germ-cell-like granules in gametocytes [PMID:38702310]. Proximity proteomics in P. yoelii place CELF2 as a stage-independent interactor of DOZI (in both female gametocytes and zygotes) and a stage-dependent interactor of ALBA4 (gametocytes but not zygotes), positioning it within the DOZI/CITH/ALBA translational repression complex [PMID:39777415]. Beyond its membership in these repression complexes and the negative RNA-binding result, no autonomous molecular function has been characterized for CELF2 in the available corpus.","teleology":[{"year":2014,"claim":"The central question of whether CELF2 is an autonomous RNA-binding regulator was answered by direct biochemistry, which distinguished it from its RNA-binding paralog and reframed how its function should be sought.","evidence":"UV-crosslinking, EMSA, and RNA immunoprecipitation-microarray (ribonomics) in P. falciparum, contrasted against PfCELF1","pmids":["25447287"],"confidence":"Medium","gaps":["Negative RNA-binding result rests on a single lab and single study","Does not test whether CELF2 binds RNA in gametocyte or sexual stages","Does not exclude RNA association mediated indirectly through partner proteins"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2019,"claim":"Given the absence of intrinsic RNA binding, the question became how CELF2 acts at all; IP-MS answered this by placing it inside the CAF1/CCR4/NOT deadenylase complex linked to translational repression.","evidence":"Reciprocal GFP-trap co-immunoprecipitation of PyCCR4-1::GFP followed by mass spectrometry with SAINT scoring in P. yoelii","pmids":["30703164"],"confidence":"Medium","gaps":["Establishes co-complex membership but no direct functional assay of CELF2 within the complex","Does not resolve whether CELF2 contacts the complex directly or via bridging subunits","Single lab, single study"],"attribution":[{"species":"Plasmodium yoelii","strain":""}]},{"year":2024,"claim":"Whether CELF2's complex membership is confined to one context was addressed by showing it resides in DOZI-associated mRNPs of two distinct morphological types across life stages.","evidence":"Co-immunoprecipitation of PfDOZI::GFP coupled to mass spectrometry in P. falciparum schizonts and gametocytes","pmids":["38702310"],"confidence":"Medium","gaps":["No direct functional assay of CELF2 itself within these mRNPs","Does not define what CELF2 contributes to granule assembly or repression","Single lab"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2025,"claim":"Proximity proteomics refined the interaction architecture, showing CELF2 is a stage-independent DOZI neighbor but only a gametocyte-stage ALBA4 neighbor, mapping it into the DOZI/CITH/ALBA translational repression complex.","evidence":"TurboID-based proximity labeling and mass spectrometry comparing female gametocytes and zygotes in P. yoelii","pmids":["39777415"],"confidence":"Medium","gaps":["Proximity does not establish direct physical contact","Functional consequence of the stage-dependent ALBA4 association is untested","Single lab, single study"],"attribution":[{"species":"Plasmodium yoelii","strain":""}]},{"year":null,"claim":"It remains unknown what CELF2 contributes mechanistically to the repression complexes it inhabits, given that it lacks autonomous RNA binding.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No loss-of-function phenotype for CELF2 itself reported","No identified direct binding partner or structural interface within the complex","No demonstration that CELF2 modulates deadenylation or translational repression activity"],"attribution":[]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["CAF1/CCR4/NOT complex","DOZI/CITH/ALBA translational repression complex","PfDOZI-associated mRNPs"],"partners":["DOZI","CITH","ALBA4","CAF1","NOT1","CCR4-1","PABP"],"other_free_text":["Negative for RNA-binding activity by UV-crosslinking and EMSA in P. falciparum asexual stages, in contrast to paralog PfCELF1 [#0]","Bound only 26 features from 22 mRNAs by ribonomics, near-negative target set [#1]","Stage-independent DOZI interactor (gametocytes and zygotes) but stage-dependent ALBA4 interactor (gametocytes only) in P. yoelii [#4]"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"25447287","id":"PMC_25447287","title":"Molecular characterization of Plasmodium falciparum Bruno/CELF RNA binding proteins.","date":"2014","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/25447287","citation_count":9,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["PfCELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"39777415","id":"","title":"Widespread release of translational repression across Plasmodium's host-to-vector transmission event.","date":"2025","source":"PLoS pathogens","url":"https://pubmed.ncbi.nlm.nih.gov/39777415","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"38702310","id":"","title":"The DEAD-box RNA helicase PfDOZI imposes opposing actions on RNA metabolism in Plasmodium falciparum.","date":"2024","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/38702310","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34673764","id":"","title":"The Plasmodium NOT1-G paralogue is an essential regulator of sexual stage maturation and parasite transmission.","date":"2021","source":"PLoS biology","url":"https://pubmed.ncbi.nlm.nih.gov/34673764","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"27230797","id":"","title":"Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems-wide studies pave the way.","date":"2016","source":"Wiley interdisciplinary reviews. RNA","url":"https://pubmed.ncbi.nlm.nih.gov/27230797","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33665945","id":"","title":"Plasmodium transcription repressor AP2-O3 regulates sex-specific identity of gene expression in female gametocytes.","date":"2021","source":"EMBO reports","url":"https://pubmed.ncbi.nlm.nih.gov/33665945","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"29985403","id":"","title":"Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development.","date":"2018","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/29985403","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"30703164","id":"","title":"Plasmodium male gametocyte development and transmission are critically regulated by the two putative deadenylases of the CAF1/CCR4/NOT complex.","date":"2019","source":"PLoS pathogens","url":"https://pubmed.ncbi.nlm.nih.gov/30703164","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"29098073","id":"","title":"Protein-mRNA interactome capture: cartography of the mRNP landscape.","date":"2016","source":"F1000Research","url":"https://pubmed.ncbi.nlm.nih.gov/29098073","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["CELF2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":12436,"output_tokens":1431,"usd":0.029386,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6347,"output_tokens":2352,"usd":0.045268,"stage2_stop_reason":"end_turn"},"total_usd":0.074654,"stage1_batch_id":"msgbatch_01SRp5hyRc82zNjddxyCCXGk","stage2_batch_id":"msgbatch_01K3BTmBazRo3pRrMvyaPMTY","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2014,\n      \"finding\": \"CELF2 (PfCELF2) was tested for RNA binding activity using UV-crosslinking and electrophoretic mobility shift assays and was found to be negative for RNA binding activity, in contrast to its paralog PfCELF1 which did bind RNA.\",\n      \"method\": \"UV-crosslinking assay and electrophoretic mobility shift assay (EMSA)\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 1 / Weak — direct in vitro biochemical assays (UV-crosslinking and EMSA) but single lab, single study; result is a negative finding\",\n      \"pmids\": [\"25447287\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2014,\n      \"finding\": \"RNA immunoprecipitation-microarray (ribonomics) analysis found that CELF2 (PfCELF2) bound to only 26 features from 22 mRNAs, indicating very few or no biologically relevant mRNA targets in asexual stages, in contrast to PfCELF1 which bound 1376 features from 1040 mRNAs.\",\n      \"method\": \"RNA immunoprecipitation coupled to DNA microarray (ribonomics)\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — immunoprecipitation-based mRNA target identification, single lab, single study; interpreted as a near-negative result\",\n      \"pmids\": [\"25447287\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2019,\n      \"finding\": \"CELF2 (as CELF2/Bruno) was identified as a component of the CAF1/CCR4/NOT complex in Plasmodium yoelii through mass spectrometric analysis of immunoprecipitated PyCCR4-1::GFP, placing CELF2 in a complex with CAF1, NOT1, DOZI, CITH, and PABP that is associated with translational repression.\",\n      \"method\": \"Co-immunoprecipitation via GFP-trap followed by mass spectrometry (SAINT analysis)\",\n      \"journal\": \"PLoS pathogens\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — reciprocal IP-MS with SAINT scoring, single lab, single study\",\n      \"pmids\": [\"30703164\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium yoelii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"CELF2 was identified as a component of PfDOZI-associated mRNPs in both schizonts (processing body-like mRNPs) and gametocytes (germ cell granule-like mRNPs) of P. falciparum, by immunoprecipitation of PfDOZI::GFP followed by mass spectrometry, indicating CELF2 participates in distinct mRNA regulatory complexes across life stages.\",\n      \"method\": \"Co-immunoprecipitation (GFP-trap) coupled to mass spectrometry\",\n      \"journal\": \"Nature communications\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — IP-MS in two parasite stages, single lab; establishes complex membership but no direct functional assay of CELF2 itself\",\n      \"pmids\": [\"38702310\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"CELF2 was identified as a stage-independent interactor of DOZI (present in both female gametocytes and zygotes) by TurboID-based proximity proteomics in P. yoelii, while CELF2 was also found as a stage-dependent interactor of ALBA4 in gametocytes (but not in zygotes), suggesting CELF2 participates in the DOZI/CITH/ALBA translational repression complex.\",\n      \"method\": \"TurboID-based proximity proteomics (proximity labeling followed by mass spectrometry)\",\n      \"journal\": \"PLoS pathogens\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — proximity proteomics with quantitative comparison across two life stages, single lab, single study\",\n      \"pmids\": [\"39777415\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium yoelii\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"CELF2 (PF3D7_1409800) in P. falciparum lacks detectable RNA-binding activity in asexual stages by direct biochemical assay, yet is a constituent of the DOZI/CITH/ALBA translational repression complex and the CAF1/CCR4/NOT complex — associations demonstrated by co-immunoprecipitation and proximity proteomics in both P. falciparum and P. yoelii across asexual, gametocyte, and zygote stages — indicating its role is mediated through complex membership rather than autonomous RNA binding.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"CELF2 (PF3D7_1409800) is a constituent of Plasmodium translational repression machinery that operates through complex membership rather than autonomous RNA engagement. In P. falciparum asexual stages, direct in vitro assays established that CELF2 lacks detectable RNA-binding activity and captures only a negligible set of mRNAs, in sharp contrast to its paralog PfCELF1 [#0, #1]. Despite this absence of intrinsic RNA binding, CELF2 is repeatedly recovered as a component of mRNP repression complexes: in P. yoelii it co-purifies with the CAF1/CCR4/NOT deadenylase complex alongside CAF1, NOT1, DOZI, CITH and PABP [#2], and in P. falciparum it is found in PfDOZI-associated mRNPs that resemble processing bodies in schizonts and germ-cell-like granules in gametocytes [#3]. Proximity proteomics in P. yoelii place CELF2 as a stage-independent interactor of DOZI (in both female gametocytes and zygotes) and a stage-dependent interactor of ALBA4 (gametocytes but not zygotes), positioning it within the DOZI/CITH/ALBA translational repression complex [#4]. Beyond its membership in these repression complexes and the negative RNA-binding result, no autonomous molecular function has been characterized for CELF2 in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2014,\n      \"claim\": \"The central question of whether CELF2 is an autonomous RNA-binding regulator was answered by direct biochemistry, which distinguished it from its RNA-binding paralog and reframed how its function should be sought.\",\n      \"evidence\": \"UV-crosslinking, EMSA, and RNA immunoprecipitation-microarray (ribonomics) in P. falciparum, contrasted against PfCELF1\",\n      \"pmids\": [\"25447287\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Negative RNA-binding result rests on a single lab and single study\",\n        \"Does not test whether CELF2 binds RNA in gametocyte or sexual stages\",\n        \"Does not exclude RNA association mediated indirectly through partner proteins\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2019,\n      \"claim\": \"Given the absence of intrinsic RNA binding, the question became how CELF2 acts at all; IP-MS answered this by placing it inside the CAF1/CCR4/NOT deadenylase complex linked to translational repression.\",\n      \"evidence\": \"Reciprocal GFP-trap co-immunoprecipitation of PyCCR4-1::GFP followed by mass spectrometry with SAINT scoring in P. yoelii\",\n      \"pmids\": [\"30703164\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Establishes co-complex membership but no direct functional assay of CELF2 within the complex\",\n        \"Does not resolve whether CELF2 contacts the complex directly or via bridging subunits\",\n        \"Single lab, single study\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium yoelii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Whether CELF2's complex membership is confined to one context was addressed by showing it resides in DOZI-associated mRNPs of two distinct morphological types across life stages.\",\n      \"evidence\": \"Co-immunoprecipitation of PfDOZI::GFP coupled to mass spectrometry in P. falciparum schizonts and gametocytes\",\n      \"pmids\": [\"38702310\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"No direct functional assay of CELF2 itself within these mRNPs\",\n        \"Does not define what CELF2 contributes to granule assembly or repression\",\n        \"Single lab\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"Proximity proteomics refined the interaction architecture, showing CELF2 is a stage-independent DOZI neighbor but only a gametocyte-stage ALBA4 neighbor, mapping it into the DOZI/CITH/ALBA translational repression complex.\",\n      \"evidence\": \"TurboID-based proximity labeling and mass spectrometry comparing female gametocytes and zygotes in P. yoelii\",\n      \"pmids\": [\"39777415\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Proximity does not establish direct physical contact\",\n        \"Functional consequence of the stage-dependent ALBA4 association is untested\",\n        \"Single lab, single study\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium yoelii\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"It remains unknown what CELF2 contributes mechanistically to the repression complexes it inhabits, given that it lacks autonomous RNA binding.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"No loss-of-function phenotype for CELF2 itself reported\",\n        \"No identified direct binding partner or structural interface within the complex\",\n        \"No demonstration that CELF2 modulates deadenylation or translational repression activity\"\n      ],\n      \"attribution\": []\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [\n      {\"term_id\": \"GO:0000932\", \"supporting_discovery_ids\": [3]},\n      {\"term_id\": \"GO:0043186\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0017148\", \"supporting_discovery_ids\": [2, 3, 4]}\n    ],\n    \"complexes\": [\n      \"CAF1/CCR4/NOT complex\",\n      \"DOZI/CITH/ALBA translational repression complex\",\n      \"PfDOZI-associated mRNPs\"\n    ],\n    \"partners\": [\n      \"DOZI\",\n      \"CITH\",\n      \"ALBA4\",\n      \"CAF1\",\n      \"NOT1\",\n      \"CCR4-1\",\n      \"PABP\"\n    ],\n    \"other_free_text\": [\n      \"Negative for RNA-binding activity by UV-crosslinking and EMSA in P. falciparum asexual stages, in contrast to paralog PfCELF1 [#0]\",\n      \"Bound only 26 features from 22 mRNAs by ribonomics, near-negative target set [#1]\",\n      \"Stage-independent DOZI interactor (gametocytes and zygotes) but stage-dependent ALBA4 interactor (gametocytes only) in P. yoelii [#4]\"\n    ]\n  }\n}","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1409800","name":null,"product":"CUGBP Elav-like family member 2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_1032700","name":null,"product":"CUGBP Elav-like family member 2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1348500","name":null,"product":"CUGBP Elav-like family member 2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"HoBo","evaluation":null}