{"gene":"PF3D7_1320500","run_date":"2026-09-08T14:19:06","timeline":{"discoveries":[],"current_model":"No mechanistic findings about PF3D7_1320500 (SNAP23) are established in the available literature; it has been identified bioinformatically as one of 18 SNARE-like proteins in the P. falciparum genome but no direct experiments characterizing its function, localization, binding partners, or enzymatic activity have been reported."},"narrative":{"mechanistic_narrative":"No mechanistic discoveries found in literature.","teleology":[],"mechanism_profile":null},"prefetch_data":{},"corpus_meta":[{"pmid":"17240462","id":"PMC_17240462","title":"Identification of Plasmodium falciparum family of SNAREs.","date":"2006","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/17240462","citation_count":38,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE","PfSNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33082261","id":"PMC_33082261","title":"The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins.","date":"2020","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/33082261","citation_count":33,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"31731198","id":"PMC_31731198","title":"Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry.","date":"2019","source":"iScience","url":"https://pubmed.ncbi.nlm.nih.gov/31731198","citation_count":21,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"22555616","id":"PMC_22555616","title":"The isoprenoid-precursor dependence of Plasmodium spp.","date":"2012","source":"Natural product reports","url":"https://pubmed.ncbi.nlm.nih.gov/22555616","citation_count":19,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"21075148","id":"PMC_21075148","title":"Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum.","date":"2010","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/21075148","citation_count":19,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"25433733","id":"PMC_25433733","title":"Computational prediction of protein interactions related to the invasion of erythrocytes by malarial parasites.","date":"2014","source":"BMC bioinformatics","url":"https://pubmed.ncbi.nlm.nih.gov/25433733","citation_count":14,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"19617396","id":"PMC_19617396","title":"The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum.","date":"2009","source":"Eukaryotic cell","url":"https://pubmed.ncbi.nlm.nih.gov/19617396","citation_count":7,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE protein","SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"19103232","id":"PMC_19103232","title":"Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasma membrane Qa-SNARE.","date":"2008","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/19103232","citation_count":7,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41972675","id":"PMC_41972675","title":"Host SNARE Proteins Mediate Lysosome and PVM Fusion to Support Plasmodium Liver Infection.","date":"2026","source":"Cells","url":"https://pubmed.ncbi.nlm.nih.gov/41972675","citation_count":1,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"42478859","id":"PMC_42478859","title":"VAMP3 vesicles support host protein recruitment and Plasmodium liver stage development.","date":"2026","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/42478859","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE protein","SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":8012,"output_tokens":722,"usd":0.017433,"stage1_stop_reason":"end_turn"},"stage2":{"model":"","input_tokens":0,"output_tokens":0,"usd":0.0},"total_usd":0.017433,"stage1_batch_id":"msgbatch_011BPjN2BL33F8cJXD1r7V7T","stage2_batch_id":"msgbatch_01Qwg6vP7qxkpL6Gsc7tajsb","note":"batch pricing = 50% of standard"},"stage1_raw":"Looking at each paper, I need to determine which ones contain mechanistic findings specifically about PF3D7_1320500 (SNAP23, a putative SNARE protein in P. falciparum).\n\n**Paper-by-paper classification:**\n\n1. **PMID:17240462** — Identifies P. falciparum SNARE family members including 18 proteins. PF3D7_1320500 is listed as a family member but the paper focuses on PfSyn5p and PfSec22p localization. No specific mechanistic findings about PF3D7_1320500/SNAP23 specifically.\n\n2. **PMID:33082261** — ZIP code of vesicle trafficking in Apicomplexa. Studies TgVps45, Stx16, Stx6, Stx12, SLY1. Not specifically about PF3D7_1320500.\n\n3. **PMID:31731198** — Host SNARE proteins in hepatocyte invasion. Studies host SNARE proteins, not PF3D7_1320500.\n\n4. **PMID:22555616** — Isoprenoid precursor paper. Mentions SNARE protein prenylation generally; not specific to PF3D7_1320500.\n\n5. **PMID:21075148** — About PfYkt6.1, a different SNARE. Not PF3D7_1320500.\n\n6. **PMID:25433733** — Computational prediction paper. Mentions SNARE proteins generally in a predicted network. No specific experimental finding about PF3D7_1320500.\n\n7. **PMID:19617396** — About PfSec22, a different SNARE. Not PF3D7_1320500.\n\n8. **PMID:19103232** — About PfStx1, a different Qa-SNARE. Not PF3D7_1320500.\n\n9. **PMID:41972675** — Host SNARE proteins (VAMP7, VAMP8, Vti1B, Stx7) in liver stage. These are host proteins, not PF3D7_1320500.\n\n10. **PMID:42478859** — About host VAMP3. Not PF3D7_1320500.\n\nNone of the papers contain specific mechanistic findings about PF3D7_1320500/SNAP23 itself. Paper 1 identifies it as part of the P. falciparum SNARE family through bioinformatics but does not perform experiments specifically on this protein.\n\n```json\n{\n  \"discoveries\": [],\n  \"current_model\": \"No mechanistic findings about PF3D7_1320500 (SNAP23) are established in the available literature; it has been identified bioinformatically as one of 18 SNARE-like proteins in the P. falciparum genome but no direct experiments characterizing its function, localization, binding partners, or enzymatic activity have been reported.\"\n}\n```","stage2_raw":"","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1320500","name":null,"product":"SNARE protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_1418800","name":null,"product":"SNARE protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1421100","name":null,"product":"SNARE protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"SNAP23","evaluation":null}