{"gene":"PF3D7_1227500","run_date":"2026-09-08T16:26:55","timeline":{"discoveries":[{"year":2020,"finding":"In P. berghei, SOC2 (PF3D7_1227500 ortholog) stably interacts with CDK-related kinase 5 (CRK5) during gametogony, forming a divergent cyclin/CDK complex. SOC2 does not show evidence of cycling by transcription, translation, or degradation (no cycling behaviour detected). The CRK5–SOC2 complex is required for atypical mitosis during male gametogony, including DNA replication and mitotic spindle assembly; depletion of SOC2 reduces ploidy and prevents reorganization of mitotic microtubules.","method":"Co-immunoprecipitation/mass spectrometry, genetic knockdown/depletion, phosphoproteomics, live imaging","journal":"eLife","confidence":"High","confidence_rationale":"Tier 2 / Strong — reciprocal Co-IP, genetic loss-of-function with defined cellular phenotypes (spindle, DNA replication), replicated across multiple orthogonal methods in one rigorous study","pmids":["32568069"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2017,"finding":"In P. berghei, SOC2 (PBANKA_144220) is a direct substrate of CDPK4, which phosphorylates it at residue S5051 within the first 30 seconds of gametocyte activation. SOC2 carries additional phosphosites upregulated at later time points (clusters 6 and 7), suggesting it integrates signals from multiple kinases. SOC2 was shown to be crucial for assembly of the mitotic spindle during microgametogenesis.","method":"High-resolution phosphoproteomic time course, CDPK4 substrate identification, genetic knockout","journal":"Cell reports","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — phosphoproteomics with kinase mutant validation, single lab, direct substrate identification at a specific residue, but abstract-level detail only","pmids":["29141230"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2021,"finding":"The CRK5–SOC2 complex was detected in cross-linking immunoprecipitation/mass spectrometry pulldowns of ARK1 from P. berghei, placing SOC2 in the broader neighbourhood of the chromosomal passenger complex and spindle regulatory machinery during male gametogenesis.","method":"Cross-linking mass spectrometry (proximity/interaction proteomics)","journal":"Nature communications","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single pulldown experiment detecting SOC2 as a distal interaction in a broad neighbourhood, no direct functional follow-up on SOC2 itself","pmids":["42323312"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2022,"finding":"In P. falciparum, the CRK5 ortholog (PfCRK5) is required for male gametogenesis and mosquito transmission, and the body text of PMID:36154191 notes that P. berghei CRK5 interacts with the Plasmodium-specific cyclin-like protein SOC2, that SOC2 shows no evidence of cycling, and that PbCRK5 phosphorylates components of the pre-replicative complex (CDT1, CDC6 orthologue, ORC2, ORC4), placing SOC2 as the cyclin partner of CRK5 in this replication-licensing context.","method":"Review/discussion of prior Co-IP data (Balestra et al., 2020) within context of P. falciparum CRK5 characterization; no new SOC2-specific experiment","journal":"mBio","confidence":"Low","confidence_rationale":"Tier 3 / Weak — confirmatory mention of prior findings, no new direct experiment on SOC2 in this paper","pmids":["36154191"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]}],"current_model":"SOC2 (PF3D7_1227500) functions as a Plasmodium-specific, non-cycling cyclin-like protein that forms a stable complex with CDK-related kinase 5 (CRK5) during male gametogony; it is phosphorylated by CDPK4 at S5051 upon gametocyte activation and is required for mitotic spindle assembly and DNA replication licensing during male gametogenesis, thereby controlling mosquito transmission."},"narrative":{"mechanistic_narrative":"SOC2 (PF3D7_1227500) is a Plasmodium-specific, non-cycling cyclin-like protein that serves as the partner of CDK-related kinase 5 (CRK5) to drive the atypical mitosis of male gametogony [PMID:32568069]. Studies of the P. berghei ortholog show that SOC2 stably associates with CRK5 to form a divergent cyclin/CDK complex, and — unlike canonical cyclins — SOC2 shows no evidence of cycling by transcription, translation, or degradation [PMID:32568069]. Genetic depletion of SOC2 reduces ploidy and prevents reorganization of mitotic microtubules, establishing that the CRK5–SOC2 complex is required for DNA replication and mitotic spindle assembly during microgametogenesis [PMID:32568069]. SOC2 is a direct substrate of CDPK4, which phosphorylates it at S5051 within the first 30 seconds of gametocyte activation, with additional phosphosites accumulating later, indicating that SOC2 integrates signals from multiple kinases at the onset of gametogony [PMID:29141230]. Beyond its role as the CRK5 cyclin partner in male gametogenesis, no further mechanistic detail for SOC2 itself has been characterized in the available corpus.","teleology":[{"year":2017,"claim":"Establishing which effectors relay the CDPK4 activation signal at the start of gametogony identified SOC2 as an early, direct kinase substrate linked to spindle assembly.","evidence":"High-resolution phosphoproteomic time course with CDPK4 substrate identification and genetic knockout in P. berghei","pmids":["29141230"],"confidence":"Medium","gaps":["Functional consequence of the S5051 phosphosite not dissected by phosphomutant rescue","Identity of the later-acting kinases contributing additional phosphosites unknown","Molecular partners of SOC2 not defined at this stage"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2020,"claim":"Defining SOC2's binding partner and loss-of-function phenotype revealed it as a non-cycling cyclin-like partner of CRK5 controlling atypical mitosis rather than a passive substrate.","evidence":"Reciprocal Co-IP/mass spectrometry, genetic depletion with ploidy and microtubule phenotyping, phosphoproteomics and live imaging in P. berghei","pmids":["32568069"],"confidence":"High","gaps":["Structural basis of the divergent CRK5–SOC2 interaction not resolved","Whether SOC2 confers substrate specificity or activation to CRK5 not directly tested","Function outside male gametogony not addressed"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2021,"claim":"Cross-linking proteomics placed the CRK5–SOC2 complex within the broader spindle-regulatory neighbourhood, hinting at connections to the chromosomal passenger machinery.","evidence":"Cross-linking immunoprecipitation/mass spectrometry pulldown of ARK1 in P. berghei","pmids":["42323312"],"confidence":"Low","gaps":["Single pulldown detecting SOC2 as a distal interaction, no functional follow-up on SOC2","Direct SOC2–ARK1 contact versus indirect co-complex membership unresolved"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2022,"claim":"Characterization of the P. falciparum CRK5 ortholog contextualized SOC2 as the cyclin partner in replication licensing, linking the complex to phosphorylation of pre-replicative components.","evidence":"Review/discussion of prior Co-IP data within P. falciparum CRK5 characterization; no new SOC2-specific experiment","pmids":["36154191"],"confidence":"Low","gaps":["No new direct experiment on SOC2 in P. falciparum","Whether P. falciparum SOC2 behaves as its P. berghei ortholog not tested","SOC2 role in phosphorylating pre-replicative complex members not directly demonstrated"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":null,"claim":"How SOC2 mechanistically activates or directs CRK5 substrate choice, and its structural and functional properties in P. falciparum itself, remain unknown.","evidence":"","pmids":[],"confidence":"Low","gaps":["No structural model of the CRK5–SOC2 complex","No direct functional characterization of P. falciparum SOC2","Role of individual phosphosites in complex activity untested"],"attribution":[]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["CRK5–SOC2 cyclin/CDK complex"],"partners":["CRK5 (CDK-RELATED KINASE 5)","CDPK4 (UPSTREAM KINASE THAT PHOSPHORYLATES SOC2 AT S5051)"],"other_free_text":["Plasmodium-specific, non-cycling cyclin-like protein","Direct CDPK4 substrate phosphorylated at S5051 within 30 s of gametocyte activation","Required for DNA replication and mitotic spindle assembly during male gametogony (microgametogenesis)","Depletion reduces ploidy and prevents reorganization of mitotic microtubules in P. berghei","Detected in the broader ARK1/chromosomal passenger complex neighbourhood by cross-linking proteomics (Low confidence)"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"32568069","id":"PMC_32568069","title":"A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission.","date":"2020","source":"eLife","url":"https://pubmed.ncbi.nlm.nih.gov/32568069","citation_count":43,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"42323312","id":"","title":"A modular chromosomal passenger complex rewires chromosome segregation in Plasmodium berghei.","date":"2026","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/42323312","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"38563493","id":"","title":"The molecular mechanisms driving Plasmodium cell division.","date":"2024","source":"Biochemical Society transactions","url":"https://pubmed.ncbi.nlm.nih.gov/38563493","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"36154191","id":"","title":"Plasmodium falciparum CRK5 Is Critical for Male Gametogenesis and Infection of the Mosquito.","date":"2022","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/36154191","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34946106","id":"","title":"Structural and Functional Insights into the Microtubule Organizing Centers of Toxoplasma gondii and Plasmodium spp.","date":"2021","source":"Microorganisms","url":"https://pubmed.ncbi.nlm.nih.gov/34946106","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":true,"competing_organism_match":"Toxoplasma","competing_organism_only":true},{"pmid":"33762339","id":"","title":"Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.","date":"2021","source":"Science advances","url":"https://pubmed.ncbi.nlm.nih.gov/33762339","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"39388903","id":"","title":"Exploration and characterization of the antimalarial activity of cyclopropyl carboxamides that target the mitochondrial protein, cytochrome b.","date":"2024","source":"European journal of medicinal chemistry","url":"https://pubmed.ncbi.nlm.nih.gov/39388903","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34026661","id":"","title":"How Many Is Enough? - Challenges of Multinucleated Cell Division in Malaria Parasites.","date":"2021","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/34026661","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"29141230","id":"","title":"Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation.","date":"2017","source":"Cell reports","url":"https://pubmed.ncbi.nlm.nih.gov/29141230","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33912479","id":"","title":"The Modular Circuitry of Apicomplexan Cell Division Plasticity.","date":"2021","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/33912479","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SOC2"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":12305,"output_tokens":1296,"usd":0.028178,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6182,"output_tokens":2244,"usd":0.043505,"stage2_stop_reason":"end_turn"},"total_usd":0.071683,"stage1_batch_id":"msgbatch_01NE1MTa8x1hW7Lo4tAaNzY1","stage2_batch_id":"msgbatch_0141vaQdeFvbo2q39AinvXM9","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2020,\n      \"finding\": \"In P. berghei, SOC2 (PF3D7_1227500 ortholog) stably interacts with CDK-related kinase 5 (CRK5) during gametogony, forming a divergent cyclin/CDK complex. SOC2 does not show evidence of cycling by transcription, translation, or degradation (no cycling behaviour detected). The CRK5–SOC2 complex is required for atypical mitosis during male gametogony, including DNA replication and mitotic spindle assembly; depletion of SOC2 reduces ploidy and prevents reorganization of mitotic microtubules.\",\n      \"method\": \"Co-immunoprecipitation/mass spectrometry, genetic knockdown/depletion, phosphoproteomics, live imaging\",\n      \"journal\": \"eLife\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — reciprocal Co-IP, genetic loss-of-function with defined cellular phenotypes (spindle, DNA replication), replicated across multiple orthogonal methods in one rigorous study\",\n      \"pmids\": [\"32568069\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"In P. berghei, SOC2 (PBANKA_144220) is a direct substrate of CDPK4, which phosphorylates it at residue S5051 within the first 30 seconds of gametocyte activation. SOC2 carries additional phosphosites upregulated at later time points (clusters 6 and 7), suggesting it integrates signals from multiple kinases. SOC2 was shown to be crucial for assembly of the mitotic spindle during microgametogenesis.\",\n      \"method\": \"High-resolution phosphoproteomic time course, CDPK4 substrate identification, genetic knockout\",\n      \"journal\": \"Cell reports\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — phosphoproteomics with kinase mutant validation, single lab, direct substrate identification at a specific residue, but abstract-level detail only\",\n      \"pmids\": [\"29141230\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2021,\n      \"finding\": \"The CRK5–SOC2 complex was detected in cross-linking immunoprecipitation/mass spectrometry pulldowns of ARK1 from P. berghei, placing SOC2 in the broader neighbourhood of the chromosomal passenger complex and spindle regulatory machinery during male gametogenesis.\",\n      \"method\": \"Cross-linking mass spectrometry (proximity/interaction proteomics)\",\n      \"journal\": \"Nature communications\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single pulldown experiment detecting SOC2 as a distal interaction in a broad neighbourhood, no direct functional follow-up on SOC2 itself\",\n      \"pmids\": [\"42323312\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"In P. falciparum, the CRK5 ortholog (PfCRK5) is required for male gametogenesis and mosquito transmission, and the body text of PMID:36154191 notes that P. berghei CRK5 interacts with the Plasmodium-specific cyclin-like protein SOC2, that SOC2 shows no evidence of cycling, and that PbCRK5 phosphorylates components of the pre-replicative complex (CDT1, CDC6 orthologue, ORC2, ORC4), placing SOC2 as the cyclin partner of CRK5 in this replication-licensing context.\",\n      \"method\": \"Review/discussion of prior Co-IP data (Balestra et al., 2020) within context of P. falciparum CRK5 characterization; no new SOC2-specific experiment\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — confirmatory mention of prior findings, no new direct experiment on SOC2 in this paper\",\n      \"pmids\": [\"36154191\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"SOC2 (PF3D7_1227500) functions as a Plasmodium-specific, non-cycling cyclin-like protein that forms a stable complex with CDK-related kinase 5 (CRK5) during male gametogony; it is phosphorylated by CDPK4 at S5051 upon gametocyte activation and is required for mitotic spindle assembly and DNA replication licensing during male gametogenesis, thereby controlling mosquito transmission.\"\n}\n```","stage2_raw":"```json\n{\n  \"mechanistic_narrative\": \"SOC2 (PF3D7_1227500) is a Plasmodium-specific, non-cycling cyclin-like protein that serves as the partner of CDK-related kinase 5 (CRK5) to drive the atypical mitosis of male gametogony [#0]. Studies of the P. berghei ortholog show that SOC2 stably associates with CRK5 to form a divergent cyclin/CDK complex, and — unlike canonical cyclins — SOC2 shows no evidence of cycling by transcription, translation, or degradation [#0]. Genetic depletion of SOC2 reduces ploidy and prevents reorganization of mitotic microtubules, establishing that the CRK5–SOC2 complex is required for DNA replication and mitotic spindle assembly during microgametogenesis [#0]. SOC2 is a direct substrate of CDPK4, which phosphorylates it at S5051 within the first 30 seconds of gametocyte activation, with additional phosphosites accumulating later, indicating that SOC2 integrates signals from multiple kinases at the onset of gametogony [#1]. Beyond its role as the CRK5 cyclin partner in male gametogenesis, no further mechanistic detail for SOC2 itself has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2017,\n      \"claim\": \"Establishing which effectors relay the CDPK4 activation signal at the start of gametogony identified SOC2 as an early, direct kinase substrate linked to spindle assembly.\",\n      \"evidence\": \"High-resolution phosphoproteomic time course with CDPK4 substrate identification and genetic knockout in P. berghei\",\n      \"pmids\": [\"29141230\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Functional consequence of the S5051 phosphosite not dissected by phosphomutant rescue\", \"Identity of the later-acting kinases contributing additional phosphosites unknown\", \"Molecular partners of SOC2 not defined at this stage\"],\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2020,\n      \"claim\": \"Defining SOC2's binding partner and loss-of-function phenotype revealed it as a non-cycling cyclin-like partner of CRK5 controlling atypical mitosis rather than a passive substrate.\",\n      \"evidence\": \"Reciprocal Co-IP/mass spectrometry, genetic depletion with ploidy and microtubule phenotyping, phosphoproteomics and live imaging in P. berghei\",\n      \"pmids\": [\"32568069\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Structural basis of the divergent CRK5–SOC2 interaction not resolved\", \"Whether SOC2 confers substrate specificity or activation to CRK5 not directly tested\", \"Function outside male gametogony not addressed\"],\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2021,\n      \"claim\": \"Cross-linking proteomics placed the CRK5–SOC2 complex within the broader spindle-regulatory neighbourhood, hinting at connections to the chromosomal passenger machinery.\",\n      \"evidence\": \"Cross-linking immunoprecipitation/mass spectrometry pulldown of ARK1 in P. berghei\",\n      \"pmids\": [\"42323312\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"Single pulldown detecting SOC2 as a distal interaction, no functional follow-up on SOC2\", \"Direct SOC2–ARK1 contact versus indirect co-complex membership unresolved\"],\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Characterization of the P. falciparum CRK5 ortholog contextualized SOC2 as the cyclin partner in replication licensing, linking the complex to phosphorylation of pre-replicative components.\",\n      \"evidence\": \"Review/discussion of prior Co-IP data within P. falciparum CRK5 characterization; no new SOC2-specific experiment\",\n      \"pmids\": [\"36154191\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No new direct experiment on SOC2 in P. falciparum\", \"Whether P. falciparum SOC2 behaves as its P. berghei ortholog not tested\", \"SOC2 role in phosphorylating pre-replicative complex members not directly demonstrated\"],\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How SOC2 mechanistically activates or directs CRK5 substrate choice, and its structural and functional properties in P. falciparum itself, remain unknown.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No structural model of the CRK5–SOC2 complex\", \"No direct functional characterization of P. falciparum SOC2\", \"Role of individual phosphosites in complex activity untested\"],\n      \"attribution\": []\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0016538\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005819\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0007140\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"complexes\": [\n      \"CRK5–SOC2 cyclin/CDK complex\"\n    ],\n    \"partners\": [\n      \"CRK5 (CDK-related kinase 5)\",\n      \"CDPK4 (upstream kinase that phosphorylates SOC2 at S5051)\"\n    ],\n    \"other_free_text\": [\n      \"Plasmodium-specific, non-cycling cyclin-like protein\",\n      \"Direct CDPK4 substrate phosphorylated at S5051 within 30 s of gametocyte activation\",\n      \"Required for DNA replication and mitotic spindle assembly during male gametogony (microgametogenesis)\",\n      \"Depletion reduces ploidy and prevents reorganization of mitotic microtubules in P. berghei\",\n      \"Detected in the broader ARK1/chromosomal passenger complex neighbourhood by cross-linking proteomics (Low confidence)\"\n    ]\n  }\n}\n```","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1227500","name":null,"product":"protein SOC2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_1442200","name":null,"product":"protein SOC2","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1446900","name":null,"product":"protein SOC2, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"SOC2","evaluation":null}