{"gene":"PF3D7_1209300","run_date":"2026-09-08T19:44:17","timeline":{"discoveries":[{"year":2017,"finding":"TRZ (PF3D7_1209300) was identified as a telomere repeat-binding protein in P. falciparum that lacks a canonical MYB domain and instead binds duplex telomere repeats via a C2H2-type zinc finger domain, as shown by in vitro DNA-binding assays and in vivo ChIP experiments demonstrating high-specificity binding to the telomeric tract and interstitial telomere repeats upstream of subtelomeric virulence genes.","method":"In vitro DNA-binding assay; ChIP-seq (in vivo occupancy mapping)","journal":"Nature microbiology","confidence":"High","confidence_rationale":"Tier 2 / Strong — multiple orthogonal methods (in vitro binding assay + in vivo ChIP-seq) in a single focused study; independently summarized in multiple subsequent papers","pmids":["28288093"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2017,"finding":"Conditional depletion of TRZ (PF3D7_1209300) revealed that it is required for telomere length homeostasis and for efficient cell cycle progression in P. falciparum blood-stage parasites.","method":"Conditional depletion (genetic loss-of-function) with telomere length measurement and cell cycle analysis as readouts","journal":"Nature microbiology","confidence":"High","confidence_rationale":"Tier 2 / Strong — clean conditional KO with two orthogonal cellular phenotype readouts (telomere length and cell cycle), single focused study; replicated by reference in multiple subsequent reviews","pmids":["28288093"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2017,"finding":"TRZ (PF3D7_1209300) binds to and regulates the expression of 5S rDNA genes in P. falciparum, and phylogenetic analysis identified it as a remote functional homologue of the general transcription factor TFIIIA — a combination of telomere-binding and 5S rDNA regulation unique among eukaryotes, suggesting TRZ acquired a telomere maintenance function early in the apicomplexan lineage.","method":"ChIP-seq (5S rDNA occupancy); gene expression analysis following conditional depletion; detailed phylogenetic analysis","journal":"Nature microbiology","confidence":"High","confidence_rationale":"Tier 2 / Moderate — ChIP-seq occupancy at 5S rDNA loci plus expression changes upon depletion plus phylogenetic analysis, all in one focused study","pmids":["28288093"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2025,"finding":"TRZ (PF3D7_1209300) occupies the boundaries between non-coding and coding subtelomeric self-interacting domains (as defined by Micro-C contact maps), co-localising with AP2-P and MORC at subtelomeric fold structures, suggesting TRZ is part of a multi-protein complex at chromosome ends that contributes to maintenance of subtelomeric chromatin architecture.","method":"Micro-C (near-nucleosome resolution chromatin contact mapping) combined with ChIP-seq occupancy data","journal":"Nature microbiology","confidence":"Medium","confidence_rationale":"Tier 2 / Weak — genome-wide Micro-C plus ChIP-seq co-localisation, single lab, no direct functional perturbation of TRZ itself in this study","pmids":["40588593"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"current_model":"TRZ (PF3D7_1209300) is a C2H2-type zinc finger protein in P. falciparum that binds duplex telomere repeats in vitro and in vivo, regulates telomere length homeostasis and cell cycle progression upon conditional depletion, and also occupies and regulates 5S rDNA loci — identifying it as a remote functional homologue of transcription factor TFIIIA that acquired a telomere maintenance role early in the apicomplexan lineage; additionally, genome-wide chromatin mapping places TRZ at the boundaries of subtelomeric fold structures together with AP2-P and MORC, implicating it in higher-order subtelomeric chromatin organisation."},"narrative":{"mechanistic_narrative":"TRZ (PF3D7_1209300) is a sequence-specific DNA-binding protein of Plasmodium falciparum that couples telomere maintenance to chromosome-end organization and 5S rDNA transcription [PMID:28288093]. Unlike canonical MYB-domain telomere factors, TRZ recognizes duplex telomeric repeats through a C2H2-type zinc finger domain, binding both the terminal telomeric tract and interstitial telomere repeats upstream of subtelomeric virulence genes in vitro and in vivo [PMID:28288093]. Conditional depletion establishes that TRZ is required for telomere length homeostasis and efficient blood-stage cell cycle progression [PMID:28288093]. Beyond telomeres, TRZ occupies and regulates 5S rDNA loci, and phylogenetic analysis identifies it as a remote functional homologue of the general transcription factor TFIIIA that acquired a telomere-maintenance role early in the apicomplexan lineage [PMID:28288093]. At chromosome ends, TRZ localizes to the boundaries between non-coding and coding subtelomeric self-interacting domains, co-localizing with AP2-P and MORC at subtelomeric fold structures and thereby contributing to higher-order subtelomeric chromatin architecture [PMID:40588593].","teleology":[{"year":2017,"claim":"Establishing how P. falciparum recognizes its telomeres in the absence of a canonical MYB-domain factor, this work identified TRZ as a telomere repeat-binding protein using a non-canonical C2H2 zinc finger.","evidence":"In vitro DNA-binding assays plus in vivo ChIP-seq occupancy mapping in P. falciparum blood-stage parasites","pmids":["28288093"],"confidence":"High","gaps":["No structural model of the zinc finger-telomere DNA interface","Binding affinity and stoichiometry not quantified","Recruitment relative to other chromosome-end factors not resolved"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2017,"claim":"To test whether TRZ binding is functionally consequential, conditional depletion showed it is required for telomere length homeostasis and cell cycle progression, defining a cellular role rather than mere occupancy.","evidence":"Conditional genetic loss-of-function with telomere length measurement and cell cycle analysis as readouts","pmids":["28288093"],"confidence":"High","gaps":["Mechanism linking TRZ loss to telomere length change unresolved","Whether the cell cycle defect is a direct consequence or secondary to telomere dysfunction unclear"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2017,"claim":"Addressing whether telomere binding was TRZ's sole role, the same study found it also binds and regulates 5S rDNA and is a remote functional homologue of TFIIIA, revealing an unusual dual telomere/rDNA function unique among eukaryotes.","evidence":"ChIP-seq occupancy at 5S rDNA loci, expression analysis after depletion, and phylogenetic analysis in P. falciparum","pmids":["28288093"],"confidence":"High","gaps":["Whether telomere and 5S rDNA functions are mechanistically coupled unknown","Direction and mechanism of 5S rDNA transcriptional regulation not detailed"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2025,"claim":"To place TRZ within chromosome-end architecture, chromatin contact mapping showed it occupies boundaries of subtelomeric self-interacting domains alongside AP2-P and MORC, implicating it in higher-order subtelomeric chromatin organization.","evidence":"Micro-C near-nucleosome-resolution contact mapping combined with ChIP-seq co-localization in P. falciparum","pmids":["40588593"],"confidence":"Medium","gaps":["No direct functional perturbation of TRZ in this study","Whether TRZ is required to establish or maintain the fold boundaries not tested","Physical association with AP2-P/MORC inferred from co-localization, not biochemically demonstrated"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":null,"claim":"How TRZ mechanistically integrates telomere length control, 5S rDNA regulation, and subtelomeric fold architecture, and whether these depend on a shared protein complex, remains unresolved.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No biochemical characterization of a TRZ-containing complex","No structural basis for dual telomere/5S rDNA recognition","Direct role in fold-boundary maintenance untested by perturbation"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["Subtelomeric fold-boundary assembly co-localizing with AP2-P and MORC (inferred from co-localization, not biochemically isolated) [#3]"],"partners":["AP2-P (CO-LOCALIZATION AT SUBTELOMERIC FOLD BOUNDARIES) [#3]","MORC (CO-LOCALIZATION AT SUBTELOMERIC FOLD BOUNDARIES) [#3]"],"other_free_text":["Binds duplex telomeric repeats and interstitial telomere repeats upstream of subtelomeric virulence genes [#0]","Remote functional homologue of the general transcription factor TFIIIA; telomere-maintenance role acquired early in the apicomplexan lineage [#2]","Uses a C2H2-type zinc finger for telomere recognition rather than a canonical MYB domain [#0]"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"20955606","id":"PMC_20955606","title":"Quantitative trait loci mapping reveals candidate pathways regulating cell cycle duration in Plasmodium falciparum.","date":"2010","source":"BMC genomics","url":"https://pubmed.ncbi.nlm.nih.gov/20955606","citation_count":39,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["PFL0465c"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"28288093","id":"PMC_28288093","title":"Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA.","date":"2017","source":"Nature microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/28288093","citation_count":20,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["curated_ref"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41001417","id":"","title":"Plasmodium telomere maintenance: uncovering the Achilles' heel for novel antimalarials.","date":"2025","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/41001417","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"40588593","id":"","title":"High-resolution map of the Plasmodium falciparum genome reveals MORC/ApiAP2-mediated links between distant, functionally related genes.","date":"2025","source":"Nature microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/40588593","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"35273922","id":"","title":"Plasmodium falciparum GBP2 Is a Telomere-Associated Protein That Binds to G-Quadruplex DNA and RNA.","date":"2022","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/35273922","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"38074093","id":"","title":"Telomere maintenance in African trypanosomes.","date":"2023","source":"Frontiers in molecular biosciences","url":"https://pubmed.ncbi.nlm.nih.gov/38074093","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33906919","id":"","title":"The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum.","date":"2021","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/33906919","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"35288749","id":"","title":"Genome-wide landscape of ApiAP2 transcription factors reveals a heterochromatin-associated regulatory network during Plasmodium falciparum blood-stage development.","date":"2022","source":"Nucleic acids research","url":"https://pubmed.ncbi.nlm.nih.gov/35288749","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"31220867","id":"","title":"What functional genomics has taught us about transcriptional regulation in malaria parasites.","date":"2019","source":"Briefings in functional genomics","url":"https://pubmed.ncbi.nlm.nih.gov/31220867","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"32816370","id":"","title":"Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite.","date":"2020","source":"Molecular systems biology","url":"https://pubmed.ncbi.nlm.nih.gov/32816370","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"28790200","id":"","title":"Chromosome End Repair and Genome Stability in Plasmodium falciparum.","date":"2017","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/28790200","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["TRZ"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":12946,"output_tokens":1246,"usd":0.028764,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6152,"output_tokens":2511,"usd":0.046767,"stage2_stop_reason":"end_turn"},"total_usd":0.075531,"stage1_batch_id":"msgbatch_01SRp5hyRc82zNjddxyCCXGk","stage2_batch_id":"msgbatch_01K3BTmBazRo3pRrMvyaPMTY","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2017,\n      \"finding\": \"TRZ (PF3D7_1209300) was identified as a telomere repeat-binding protein in P. falciparum that lacks a canonical MYB domain and instead binds duplex telomere repeats via a C2H2-type zinc finger domain, as shown by in vitro DNA-binding assays and in vivo ChIP experiments demonstrating high-specificity binding to the telomeric tract and interstitial telomere repeats upstream of subtelomeric virulence genes.\",\n      \"method\": \"In vitro DNA-binding assay; ChIP-seq (in vivo occupancy mapping)\",\n      \"journal\": \"Nature microbiology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — multiple orthogonal methods (in vitro binding assay + in vivo ChIP-seq) in a single focused study; independently summarized in multiple subsequent papers\",\n      \"pmids\": [\"28288093\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"Conditional depletion of TRZ (PF3D7_1209300) revealed that it is required for telomere length homeostasis and for efficient cell cycle progression in P. falciparum blood-stage parasites.\",\n      \"method\": \"Conditional depletion (genetic loss-of-function) with telomere length measurement and cell cycle analysis as readouts\",\n      \"journal\": \"Nature microbiology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Strong — clean conditional KO with two orthogonal cellular phenotype readouts (telomere length and cell cycle), single focused study; replicated by reference in multiple subsequent reviews\",\n      \"pmids\": [\"28288093\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2017,\n      \"finding\": \"TRZ (PF3D7_1209300) binds to and regulates the expression of 5S rDNA genes in P. falciparum, and phylogenetic analysis identified it as a remote functional homologue of the general transcription factor TFIIIA — a combination of telomere-binding and 5S rDNA regulation unique among eukaryotes, suggesting TRZ acquired a telomere maintenance function early in the apicomplexan lineage.\",\n      \"method\": \"ChIP-seq (5S rDNA occupancy); gene expression analysis following conditional depletion; detailed phylogenetic analysis\",\n      \"journal\": \"Nature microbiology\",\n      \"confidence\": \"High\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — ChIP-seq occupancy at 5S rDNA loci plus expression changes upon depletion plus phylogenetic analysis, all in one focused study\",\n      \"pmids\": [\"28288093\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2025,\n      \"finding\": \"TRZ (PF3D7_1209300) occupies the boundaries between non-coding and coding subtelomeric self-interacting domains (as defined by Micro-C contact maps), co-localising with AP2-P and MORC at subtelomeric fold structures, suggesting TRZ is part of a multi-protein complex at chromosome ends that contributes to maintenance of subtelomeric chromatin architecture.\",\n      \"method\": \"Micro-C (near-nucleosome resolution chromatin contact mapping) combined with ChIP-seq occupancy data\",\n      \"journal\": \"Nature microbiology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Weak — genome-wide Micro-C plus ChIP-seq co-localisation, single lab, no direct functional perturbation of TRZ itself in this study\",\n      \"pmids\": [\"40588593\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"TRZ (PF3D7_1209300) is a C2H2-type zinc finger protein in P. falciparum that binds duplex telomere repeats in vitro and in vivo, regulates telomere length homeostasis and cell cycle progression upon conditional depletion, and also occupies and regulates 5S rDNA loci — identifying it as a remote functional homologue of transcription factor TFIIIA that acquired a telomere maintenance role early in the apicomplexan lineage; additionally, genome-wide chromatin mapping places TRZ at the boundaries of subtelomeric fold structures together with AP2-P and MORC, implicating it in higher-order subtelomeric chromatin organisation.\"\n}\n```","stage2_raw":"```json\n{\n  \"mechanistic_narrative\": \"TRZ (PF3D7_1209300) is a sequence-specific DNA-binding protein of Plasmodium falciparum that couples telomere maintenance to chromosome-end organization and 5S rDNA transcription [#0, #2]. Unlike canonical MYB-domain telomere factors, TRZ recognizes duplex telomeric repeats through a C2H2-type zinc finger domain, binding both the terminal telomeric tract and interstitial telomere repeats upstream of subtelomeric virulence genes in vitro and in vivo [#0]. Conditional depletion establishes that TRZ is required for telomere length homeostasis and efficient blood-stage cell cycle progression [#1]. Beyond telomeres, TRZ occupies and regulates 5S rDNA loci, and phylogenetic analysis identifies it as a remote functional homologue of the general transcription factor TFIIIA that acquired a telomere-maintenance role early in the apicomplexan lineage [#2]. At chromosome ends, TRZ localizes to the boundaries between non-coding and coding subtelomeric self-interacting domains, co-localizing with AP2-P and MORC at subtelomeric fold structures and thereby contributing to higher-order subtelomeric chromatin architecture [#3].\",\n  \"teleology\": [\n    {\n      \"year\": 2017,\n      \"claim\": \"Establishing how P. falciparum recognizes its telomeres in the absence of a canonical MYB-domain factor, this work identified TRZ as a telomere repeat-binding protein using a non-canonical C2H2 zinc finger.\",\n      \"evidence\": \"In vitro DNA-binding assays plus in vivo ChIP-seq occupancy mapping in P. falciparum blood-stage parasites\",\n      \"pmids\": [\"28288093\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"No structural model of the zinc finger-telomere DNA interface\", \"Binding affinity and stoichiometry not quantified\", \"Recruitment relative to other chromosome-end factors not resolved\"],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2017,\n      \"claim\": \"To test whether TRZ binding is functionally consequential, conditional depletion showed it is required for telomere length homeostasis and cell cycle progression, defining a cellular role rather than mere occupancy.\",\n      \"evidence\": \"Conditional genetic loss-of-function with telomere length measurement and cell cycle analysis as readouts\",\n      \"pmids\": [\"28288093\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Mechanism linking TRZ loss to telomere length change unresolved\", \"Whether the cell cycle defect is a direct consequence or secondary to telomere dysfunction unclear\"],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2017,\n      \"claim\": \"Addressing whether telomere binding was TRZ's sole role, the same study found it also binds and regulates 5S rDNA and is a remote functional homologue of TFIIIA, revealing an unusual dual telomere/rDNA function unique among eukaryotes.\",\n      \"evidence\": \"ChIP-seq occupancy at 5S rDNA loci, expression analysis after depletion, and phylogenetic analysis in P. falciparum\",\n      \"pmids\": [\"28288093\"],\n      \"confidence\": \"High\",\n      \"gaps\": [\"Whether telomere and 5S rDNA functions are mechanistically coupled unknown\", \"Direction and mechanism of 5S rDNA transcriptional regulation not detailed\"],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2025,\n      \"claim\": \"To place TRZ within chromosome-end architecture, chromatin contact mapping showed it occupies boundaries of subtelomeric self-interacting domains alongside AP2-P and MORC, implicating it in higher-order subtelomeric chromatin organization.\",\n      \"evidence\": \"Micro-C near-nucleosome-resolution contact mapping combined with ChIP-seq co-localization in P. falciparum\",\n      \"pmids\": [\"40588593\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"No direct functional perturbation of TRZ in this study\", \"Whether TRZ is required to establish or maintain the fold boundaries not tested\", \"Physical association with AP2-P/MORC inferred from co-localization, not biochemically demonstrated\"],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"How TRZ mechanistically integrates telomere length control, 5S rDNA regulation, and subtelomeric fold architecture, and whether these depend on a shared protein complex, remains unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"No biochemical characterization of a TRZ-containing complex\", \"No structural basis for dual telomere/5S rDNA recognition\", \"Direct role in fold-boundary maintenance untested by perturbation\"],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0042162\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0003676\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0008270\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0003700\", \"supporting_discovery_ids\": [2]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0000781\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0005634\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0000723\", \"supporting_discovery_ids\": [1]},\n      {\"term_id\": \"GO:0007049\", \"supporting_discovery_ids\": [1]},\n      {\"term_id\": \"GO:0006384\", \"supporting_discovery_ids\": [2]},\n      {\"term_id\": \"GO:0031507\", \"supporting_discovery_ids\": [3]}\n    ],\n    \"complexes\": [\n      \"Subtelomeric fold-boundary assembly co-localizing with AP2-P and MORC (inferred from co-localization, not biochemically isolated) [#3]\"\n    ],\n    \"partners\": [\n      \"AP2-P (co-localization at subtelomeric fold boundaries) [#3]\",\n      \"MORC (co-localization at subtelomeric fold boundaries) [#3]\"\n    ],\n    \"other_free_text\": [\n      \"Binds duplex telomeric repeats and interstitial telomere repeats upstream of subtelomeric virulence genes [#0]\",\n      \"Remote functional homologue of the general transcription factor TFIIIA; telomere-maintenance role acquired early in the apicomplexan lineage [#2]\",\n      \"Uses a C2H2-type zinc finger for telomere recognition rather than a canonical MYB domain [#0]\"\n    ]\n  }\n}\n```","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1209300","name":null,"product":"telomere repeat-binding zinc finger protein","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_0607700","name":null,"product":"telomere repeat-binding zinc finger protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1309200","name":null,"product":"telomere repeat-binding zinc finger protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"TRZ","evaluation":null}