{"gene":"PF3D7_1104100","run_date":"2026-09-08T12:51:28","timeline":{"discoveries":[{"year":2006,"finding":"PF3D7_1104100 (SYN13) was identified as one of 18 SNARE-like proteins in the P. falciparum genome via bioinformatics analysis; it was classified into a P. falciparum-specific syntaxin-like subfamily. The study determined subcellular localizations of select family members by GFP-tagging, but direct localization of SYN13 specifically was not reported.","method":"Bioinformatics/phylogenetic analysis of P. falciparum genome; GFP-tagging of select family members (PfSyn5p and PfSec22p, not SYN13 directly)","journal":"Molecular and biochemical parasitology","confidence":"Low","confidence_rationale":"Tier 4 / Weak — computational identification only; no direct experiment performed on SYN13/PF3D7_1104100 specifically","pmids":["17240462"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2008,"finding":"Seven Qa-SNAREs were identified in the P. falciparum genome including PF3D7_1104100 (SYN13); comprehensive sequence alignments were used to predict intracellular locations for all seven, but direct experimental localization was only confirmed for PfStx1 (not SYN13).","method":"Genome mining, sequence alignment, gene structure confirmation; direct localization experiment performed only on PfStx1","journal":"Molecular and biochemical parasitology","confidence":"Low","confidence_rationale":"Tier 4 / Weak — SYN13 was catalogued and its location predicted computationally but not experimentally validated in this study","pmids":["19103232"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2020,"finding":"In P. falciparum, the SNARE protein Stx12 (described as localizing to an endosomal-like compartment and involved in trafficking to rhoptries, micronemes, and apicoplast) and Stx16/Stx6 (implicated in inner membrane complex biogenesis) were functionally characterized; SYN13/PF3D7_1104100 was not directly studied but is listed as part of the broader P. falciparum SNARE complement assessed in this work.","method":"Conditional knockdown, co-immunoprecipitation with SEC1/Munc18 tethering factors, fluorescence microscopy","journal":"mBio","confidence":"Low","confidence_rationale":"Tier 3 / Weak — study covers the SNARE family broadly; no specific experiment on SYN13/PF3D7_1104100 is described in the abstract","pmids":["33082261"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2026,"finding":"The P. falciparum syntaxin-5-like protein PfSyn5 (described in the abstract as the parasite binding partner of the Anopheles gambiae midgut factor AgMOBP1) was identified by biochemical interaction assays. Anti-PfSyn5 polyclonal antibodies blocked malaria transmission with complete inhibition at 1 μg/mL and an estimated IC50 of ~3 ng/mL (~20 pM). Note: the abstract uses the name 'PfSyn5' for this interaction partner; based on context this may correspond to a syntaxin family member but the abstract does not explicitly map 'PfSyn5' to PF3D7_1104100. Attribution to SYN13/PF3D7_1104100 is uncertain.","method":"Biochemical interaction assays (pulldown/binding), functional infection assay with recombinant protein and blocking antibodies","journal":"bioRxiv : the preprint server for biology","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single lab, biochemical pulldown and antibody blocking; gene identity of 'PfSyn5' relative to PF3D7_1104100 is not confirmed in the abstract","pmids":["42146686"],"is_preprint":true,"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"current_model":"PF3D7_1104100 (SYN13) is a member of the Qa-SNARE/syntaxin family in P. falciparum, catalogued by genome-wide bioinformatics surveys as one of seven Qa-SNAREs and belonging to a P. falciparum-specific syntaxin-like subfamily, but no direct experiment in the available literature has established its specific subcellular localization, binding partners, enzymatic activity, or defined cellular function independently of the broader SNARE family."},"narrative":{"mechanistic_narrative":"PF3D7_1104100 (SYN13) is a Qa-SNARE/syntaxin-family protein of Plasmodium falciparum known only from genome-wide bioinformatic surveys, which catalogued it among the SNARE-like proteins of the parasite and placed it within a P. falciparum-specific syntaxin-like subfamily [PMID:17240462]; subsequent genome mining classified it as one of seven parasite Qa-SNAREs [PMID:19103232]. No direct experiment in the available corpus has established the subcellular localization, binding partners, enzymatic activity, or cellular function of SYN13 itself: in each survey, direct localization was reported only for other family members (PfSyn5p, PfSec22p, PfStx1), not SYN13 [PMID:17240462, PMID:19103232]. Broader functional studies of the P. falciparum SNARE complement characterized Stx12 and Stx16/Stx6 in trafficking and inner membrane complex biogenesis, but did not experimentally interrogate SYN13 [PMID:33082261]. Beyond its membership in the syntaxin/Qa-SNARE family, no mechanistic detail specific to PF3D7_1104100 has been characterized in the available corpus.","teleology":[{"year":2006,"claim":"Establishing the parasite's SNARE repertoire was the first step toward understanding its membrane trafficking; this survey placed SYN13 on the map as a syntaxin-like protein within a P. falciparum-specific subfamily.","evidence":"Bioinformatic and phylogenetic analysis of the P. falciparum genome, with GFP-tagging of select (non-SYN13) family members","pmids":["17240462"],"confidence":"Low","gaps":["Identification is computational only; no direct experiment was performed on SYN13/PF3D7_1104100","Subcellular localization of SYN13 was not reported","No binding partners or function assigned"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2008,"claim":"Refining the Qa-SNARE subset and predicting intracellular locations aimed to assign each syntaxin to a trafficking step, but SYN13's predicted location was never experimentally tested.","evidence":"Genome mining, sequence alignment, and gene-structure confirmation; direct localization confirmed only for PfStx1","pmids":["19103232"],"confidence":"Low","gaps":["SYN13 localization was predicted computationally, not validated","No cognate SNARE partners identified for SYN13","No functional or knockdown data for SYN13"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2020,"claim":"Functional dissection of individual parasite SNAREs began to link specific syntaxins to defined trafficking routes, yet SYN13 remained only a listed member of the assessed complement rather than an experimental subject.","evidence":"Conditional knockdown, co-immunoprecipitation with SEC1/Munc18 tethering factors, and fluorescence microscopy of Stx12 and Stx16/Stx6 (not SYN13)","pmids":["33082261"],"confidence":"Low","gaps":["No experiment in the study addresses SYN13/PF3D7_1104100 directly","SYN13 trafficking role, partners, and essentiality remain untested"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2026,"claim":"A syntaxin-5-like parasite protein ('PfSyn5') was characterized as a mosquito midgut-factor binding partner and transmission-blocking antibody target, but the abstract does not map 'PfSyn5' to PF3D7_1104100, so this cannot be attributed to SYN13.","evidence":"Biochemical interaction pulldown/binding assays plus infection assays with recombinant protein and blocking antibodies (preprint)","pmids":["42146686"],"confidence":"Low","gaps":["Gene identity of 'PfSyn5' relative to PF3D7_1104100 is not confirmed; attribution to SYN13 is uncertain","Single-lab preprint not independently confirmed","No direct evidence that SYN13 mediates the reported interaction or transmission phenotype"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":null,"claim":"The core mechanistic questions for SYN13 remain entirely open: its subcellular localization, cognate SNARE and Munc18/SEC1 partners, the membrane-fusion step it catalyzes, and its role in parasite biology are all uncharacterized in the available corpus.","evidence":"No direct experimental study of PF3D7_1104100 exists in the timeline","pmids":[],"confidence":"Low","gaps":["No experimental localization of SYN13","No identified binding partners or complex membership for SYN13 specifically","No knockdown/knockout phenotype defining its cellular function"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":[],"partners":[],"other_free_text":["Classified as a member of a P. falciparum-specific syntaxin-like subfamily of SNARE proteins [#0].","Catalogued as one of seven Qa-SNAREs identified in the P. falciparum genome [#1].","No direct experimental localization, partners, activity, or function has been established for PF3D7_1104100 itself; direct data in the surveyed corpus pertain to other family members (PfSyn5p, PfSec22p, PfStx1, Stx12, Stx16/Stx6) [#0, #1, #2].","A 2026 preprint characterizes a syntaxin-5-like protein 'PfSyn5' as a transmission-blocking target, but does not map this name to PF3D7_1104100; attribution to SYN13 is unconfirmed [#3]."]}},"prefetch_data":{},"corpus_meta":[{"pmid":"17240462","id":"PMC_17240462","title":"Identification of Plasmodium falciparum family of SNAREs.","date":"2006","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/17240462","citation_count":38,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["syntaxin","SNARE","PfSNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33082261","id":"PMC_33082261","title":"The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins.","date":"2020","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/33082261","citation_count":33,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["syntaxin","SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"31731198","id":"PMC_31731198","title":"Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry.","date":"2019","source":"iScience","url":"https://pubmed.ncbi.nlm.nih.gov/31731198","citation_count":21,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"22555616","id":"PMC_22555616","title":"The isoprenoid-precursor dependence of Plasmodium spp.","date":"2012","source":"Natural product reports","url":"https://pubmed.ncbi.nlm.nih.gov/22555616","citation_count":19,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"21075148","id":"PMC_21075148","title":"Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum.","date":"2010","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/21075148","citation_count":19,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"25433733","id":"PMC_25433733","title":"Computational prediction of protein interactions related to the invasion of erythrocytes by malarial parasites.","date":"2014","source":"BMC bioinformatics","url":"https://pubmed.ncbi.nlm.nih.gov/25433733","citation_count":14,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"19103232","id":"PMC_19103232","title":"Plasmodium falciparum secretory pathway: characterization of PfStx1, a plasma membrane Qa-SNARE.","date":"2008","source":"Molecular and biochemical parasitology","url":"https://pubmed.ncbi.nlm.nih.gov/19103232","citation_count":7,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["syntaxin","SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"19617396","id":"PMC_19617396","title":"The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum.","date":"2009","source":"Eukaryotic cell","url":"https://pubmed.ncbi.nlm.nih.gov/19617396","citation_count":7,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41972675","id":"PMC_41972675","title":"Host SNARE Proteins Mediate Lysosome and PVM Fusion to Support Plasmodium Liver Infection.","date":"2026","source":"Cells","url":"https://pubmed.ncbi.nlm.nih.gov/41972675","citation_count":1,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["syntaxin","SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"42146686","id":"PMC_42146686","title":"Disruption of the AgMOBP1-PfSyn5 interface abolishes malaria transmission.","date":"2026","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/42146686","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["syntaxin"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"42478859","id":"PMC_42478859","title":"VAMP3 vesicles support host protein recruitment and Plasmodium liver stage development.","date":"2026","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/42478859","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["SNARE"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":8548,"output_tokens":1346,"usd":0.022917,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6197,"output_tokens":2290,"usd":0.044117,"stage2_stop_reason":"end_turn"},"total_usd":0.067034,"stage1_batch_id":"msgbatch_01DisAaTypwmC8QwdMBuePHo","stage2_batch_id":"msgbatch_0184zxZTqxiEfdYYfPMfkqjb","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2006,\n      \"finding\": \"PF3D7_1104100 (SYN13) was identified as one of 18 SNARE-like proteins in the P. falciparum genome via bioinformatics analysis; it was classified into a P. falciparum-specific syntaxin-like subfamily. The study determined subcellular localizations of select family members by GFP-tagging, but direct localization of SYN13 specifically was not reported.\",\n      \"method\": \"Bioinformatics/phylogenetic analysis of P. falciparum genome; GFP-tagging of select family members (PfSyn5p and PfSec22p, not SYN13 directly)\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 4 / Weak — computational identification only; no direct experiment performed on SYN13/PF3D7_1104100 specifically\",\n      \"pmids\": [\"17240462\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2008,\n      \"finding\": \"Seven Qa-SNAREs were identified in the P. falciparum genome including PF3D7_1104100 (SYN13); comprehensive sequence alignments were used to predict intracellular locations for all seven, but direct experimental localization was only confirmed for PfStx1 (not SYN13).\",\n      \"method\": \"Genome mining, sequence alignment, gene structure confirmation; direct localization experiment performed only on PfStx1\",\n      \"journal\": \"Molecular and biochemical parasitology\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 4 / Weak — SYN13 was catalogued and its location predicted computationally but not experimentally validated in this study\",\n      \"pmids\": [\"19103232\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2020,\n      \"finding\": \"In P. falciparum, the SNARE protein Stx12 (described as localizing to an endosomal-like compartment and involved in trafficking to rhoptries, micronemes, and apicoplast) and Stx16/Stx6 (implicated in inner membrane complex biogenesis) were functionally characterized; SYN13/PF3D7_1104100 was not directly studied but is listed as part of the broader P. falciparum SNARE complement assessed in this work.\",\n      \"method\": \"Conditional knockdown, co-immunoprecipitation with SEC1/Munc18 tethering factors, fluorescence microscopy\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — study covers the SNARE family broadly; no specific experiment on SYN13/PF3D7_1104100 is described in the abstract\",\n      \"pmids\": [\"33082261\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2026,\n      \"finding\": \"The P. falciparum syntaxin-5-like protein PfSyn5 (described in the abstract as the parasite binding partner of the Anopheles gambiae midgut factor AgMOBP1) was identified by biochemical interaction assays. Anti-PfSyn5 polyclonal antibodies blocked malaria transmission with complete inhibition at 1 μg/mL and an estimated IC50 of ~3 ng/mL (~20 pM). Note: the abstract uses the name 'PfSyn5' for this interaction partner; based on context this may correspond to a syntaxin family member but the abstract does not explicitly map 'PfSyn5' to PF3D7_1104100. Attribution to SYN13/PF3D7_1104100 is uncertain.\",\n      \"method\": \"Biochemical interaction assays (pulldown/binding), functional infection assay with recombinant protein and blocking antibodies\",\n      \"journal\": \"bioRxiv : the preprint server for biology\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single lab, biochemical pulldown and antibody blocking; gene identity of 'PfSyn5' relative to PF3D7_1104100 is not confirmed in the abstract\",\n      \"pmids\": [\"42146686\"],\n      \"is_preprint\": true,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"PF3D7_1104100 (SYN13) is a member of the Qa-SNARE/syntaxin family in P. falciparum, catalogued by genome-wide bioinformatics surveys as one of seven Qa-SNAREs and belonging to a P. falciparum-specific syntaxin-like subfamily, but no direct experiment in the available literature has established its specific subcellular localization, binding partners, enzymatic activity, or defined cellular function independently of the broader SNARE family.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"PF3D7_1104100 (SYN13) is a Qa-SNARE/syntaxin-family protein of Plasmodium falciparum known only from genome-wide bioinformatic surveys, which catalogued it among the SNARE-like proteins of the parasite and placed it within a P. falciparum-specific syntaxin-like subfamily [#0]; subsequent genome mining classified it as one of seven parasite Qa-SNAREs [#1]. No direct experiment in the available corpus has established the subcellular localization, binding partners, enzymatic activity, or cellular function of SYN13 itself: in each survey, direct localization was reported only for other family members (PfSyn5p, PfSec22p, PfStx1), not SYN13 [#0, #1]. Broader functional studies of the P. falciparum SNARE complement characterized Stx12 and Stx16/Stx6 in trafficking and inner membrane complex biogenesis, but did not experimentally interrogate SYN13 [#2]. Beyond its membership in the syntaxin/Qa-SNARE family, no mechanistic detail specific to PF3D7_1104100 has been characterized in the available corpus.\"\n  ,\n  \"teleology\": [\n    {\n      \"year\": 2006,\n      \"claim\": \"Establishing the parasite's SNARE repertoire was the first step toward understanding its membrane trafficking; this survey placed SYN13 on the map as a syntaxin-like protein within a P. falciparum-specific subfamily.\",\n      \"evidence\": \"Bioinformatic and phylogenetic analysis of the P. falciparum genome, with GFP-tagging of select (non-SYN13) family members\",\n      \"pmids\": [\"17240462\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Identification is computational only; no direct experiment was performed on SYN13/PF3D7_1104100\",\n        \"Subcellular localization of SYN13 was not reported\",\n        \"No binding partners or function assigned\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2008,\n      \"claim\": \"Refining the Qa-SNARE subset and predicting intracellular locations aimed to assign each syntaxin to a trafficking step, but SYN13's predicted location was never experimentally tested.\",\n      \"evidence\": \"Genome mining, sequence alignment, and gene-structure confirmation; direct localization confirmed only for PfStx1\",\n      \"pmids\": [\"19103232\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"SYN13 localization was predicted computationally, not validated\",\n        \"No cognate SNARE partners identified for SYN13\",\n        \"No functional or knockdown data for SYN13\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2020,\n      \"claim\": \"Functional dissection of individual parasite SNAREs began to link specific syntaxins to defined trafficking routes, yet SYN13 remained only a listed member of the assessed complement rather than an experimental subject.\",\n      \"evidence\": \"Conditional knockdown, co-immunoprecipitation with SEC1/Munc18 tethering factors, and fluorescence microscopy of Stx12 and Stx16/Stx6 (not SYN13)\",\n      \"pmids\": [\"33082261\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No experiment in the study addresses SYN13/PF3D7_1104100 directly\",\n        \"SYN13 trafficking role, partners, and essentiality remain untested\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2026,\n      \"claim\": \"A syntaxin-5-like parasite protein ('PfSyn5') was characterized as a mosquito midgut-factor binding partner and transmission-blocking antibody target, but the abstract does not map 'PfSyn5' to PF3D7_1104100, so this cannot be attributed to SYN13.\",\n      \"evidence\": \"Biochemical interaction pulldown/binding assays plus infection assays with recombinant protein and blocking antibodies (preprint)\",\n      \"pmids\": [\"42146686\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Gene identity of 'PfSyn5' relative to PF3D7_1104100 is not confirmed; attribution to SYN13 is uncertain\",\n        \"Single-lab preprint not independently confirmed\",\n        \"No direct evidence that SYN13 mediates the reported interaction or transmission phenotype\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The core mechanistic questions for SYN13 remain entirely open: its subcellular localization, cognate SNARE and Munc18/SEC1 partners, the membrane-fusion step it catalyzes, and its role in parasite biology are all uncharacterized in the available corpus.\",\n      \"evidence\": \"No direct experimental study of PF3D7_1104100 exists in the timeline\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No experimental localization of SYN13\",\n        \"No identified binding partners or complex membership for SYN13 specifically\",\n        \"No knockdown/knockout phenotype defining its cellular function\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0005484\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"localization\": [],\n    \"pathway\": [],\n    \"complexes\": [],\n    \"partners\": [],\n    \"other_free_text\": [\n      \"Classified as a member of a P. falciparum-specific syntaxin-like subfamily of SNARE proteins [#0].\",\n      \"Catalogued as one of seven Qa-SNAREs identified in the P. falciparum genome [#1].\",\n      \"No direct experimental localization, partners, activity, or function has been established for PF3D7_1104100 itself; direct data in the surveyed corpus pertain to other family members (PfSyn5p, PfSec22p, PfStx1, Stx12, Stx16/Stx6) [#0, #1, #2].\",\n      \"A 2026 preprint characterizes a syntaxin-5-like protein 'PfSyn5' as a transmission-blocking target, but does not map this name to PF3D7_1104100; attribution to SYN13 is unconfirmed [#3].\"\n    ]\n  }\n}","audit_flag":{"gene":"PF3D7_1104100","tier":"IDENTITY_CHECK","verdict":"identity unverified","subtype":"names_other_cards","uniprot_band":"","rules_fired":"R12","issue":"No cited paper names this card; 2 of 4 cited papers name other catalogue genes (PF3D7_1034000, PF3D7_1243000, PF3D7_1452500). The summary may describe one of those genes."},"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1104100","name":null,"product":"syntaxin, Qa-SNARE family","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_0942800","name":null,"product":"syntaxin, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_0901700","name":null,"product":"syntaxin, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"SYN13","evaluation":null}