{"gene":"PF3D7_1024800","run_date":"2026-09-08T16:26:55","timeline":{"discoveries":[{"year":2023,"finding":"EXP3 (PF3D7_1024800) was identified as an interactor of the exported membrane protein SBP1 prior to its export (pre-export stage, 4 hpi), being 3-fold enriched at early time points in proximity-biotinylation experiments, consistent with its localization to the parasitophorous vacuole and a function in protein export.","method":"Time-resolved proximity biotinylation (TurboID fused to SBP1) combined with label-free quantitative proteomics","journal":"Journal of cell science","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — single proximity-biotinylation experiment in one lab; enrichment is quantitative but no reciprocal Co-IP or mutagenesis; EXP3 role in export supported by prior work cited in the same abstract","pmids":["37772444"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2022,"finding":"EXP3 (PF3D7_1024800) was identified as a component of the Exported Protein-Interacting Complex (EPIC), which also comprises PV1 and PV2, and EPIC was shown to interact with the PTEX protein export machinery (including P113) by immunoprecipitation studies in P. falciparum.","method":"Co-immunoprecipitation / immunoprecipitation of binding partners from in vitro P. falciparum cultures","journal":"Molecular microbiology","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — Co-IP evidence from a single lab; EPIC membership and PTEX interaction reported in multiple independent studies (Batinovic et al. 2017 and Hakamada et al. 2020 both cited), supporting moderate preponderance","pmids":["35403274"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2021,"finding":"EXP3 (PF3D7_1024800) was reported as an accessory (non-essential) component of the PTEX protein export machinery at the parasitophorous vacuole membrane; conditional depletion or disruption of EXP3 has little to no observable impact on protein export or parasite fitness in vitro, but accessory factors including EXP3 appear to aid export of virulence-relevant effector subsets in vivo.","method":"Conditional knockdown / genetic disruption with parasite growth and protein export assays (as reviewed from primary experimental literature cited)","journal":"PLoS pathogens","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — genetic loss-of-function data with defined phenotypic readout reported in multiple independent studies (review citing Batinovic et al. 2017 and others); non-essentiality in vitro replicated across labs","pmids":["33793667"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2018,"finding":"The P. berghei ortholog of EXP3 (PBANKA_0509000) was localized to the parasitophorous vacuole membrane (PVM) during both blood stage and liver stage development, identified by BioID proximity biotinylation using BirA* fused to EXP1 on the PVM.","method":"BioID proximity biotinylation (BirA*-EXP1 fusion) followed by affinity purification and LC-MS/MS; confirmed by fluorescence microscopy during blood and liver stage development","journal":"mSphere","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct localization by two complementary methods (BioID proteomics and fluorescence imaging) in a single study; liver stage localization novel finding","pmids":["29404413"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]}],"current_model":"EXP3 (PF3D7_1024800) is a parasitophorous vacuole membrane-associated protein that forms part of the Exported Protein-Interacting Complex (EPIC) together with PV1 and PV2; EPIC interacts with the core PTEX protein export translocon and with cargo proteins such as SBP1 prior to their export, and while EXP3 is dispensable for bulk protein export and parasite growth in vitro, it appears to facilitate export of specific virulence-relevant effectors in vivo; its ortholog in P. berghei also localizes to the PVM in liver stage parasites."},"narrative":{"mechanistic_narrative":"EXP3 (PF3D7_1024800) is a parasitophorous vacuole membrane-associated protein of Plasmodium that functions in the compartment where parasite effector proteins are staged for export into the host erythrocyte [PMID:37772444, PMID:33793667]. In P. falciparum it is a component of the Exported Protein-Interacting Complex (EPIC), together with PV1 and PV2, and EPIC physically associates with the PTEX export translocon (including P113) [PMID:35403274]; consistent with this, EXP3 is captured in proximity to the exported membrane protein SBP1 at an early, pre-export stage, placing it near cargo before translocation [PMID:37772444]. Functionally, EXP3 behaves as an accessory rather than a core export factor: conditional depletion or disruption has little effect on bulk protein export or parasite fitness in vitro, while accessory factors of this class contribute to export of virulence-relevant effector subsets in vivo [PMID:33793667]. The P. berghei ortholog (PBANKA_0509000) localizes to the PVM in both blood- and liver-stage parasites [PMID:29404413]. Beyond its membership in EPIC and its PVM association, no direct enzymatic activity, structural model, or defined molecular mechanism for EXP3 itself has been characterized in the available corpus.","teleology":[{"year":2018,"claim":"Establishing where the EXP3 ortholog resides answered whether it acts at the host-parasite interface, localizing it to the parasitophorous vacuole membrane across life-cycle stages.","evidence":"BioID proximity biotinylation with BirA*-EXP1 plus fluorescence microscopy in P. berghei blood and liver stages","pmids":["29404413"],"confidence":"Medium","gaps":["Localization shown for the P. berghei ortholog, not directly for PF3D7_1024800","Does not define a molecular function at the PVM","No membrane topology or orientation data"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2021,"claim":"Genetic loss-of-function testing addressed whether EXP3 is required for export, showing it is an accessory, non-essential PTEX-associated factor dispensable for bulk export in vitro but implicated in effector export in vivo.","evidence":"Conditional knockdown/genetic disruption with growth and export assays in P. falciparum (as reviewed from primary literature)","pmids":["33793667"],"confidence":"Medium","gaps":["Which specific effectors depend on EXP3 for export is not defined","The in vivo virulence contribution is inferred at the class level, not demonstrated for EXP3 individually","Mechanism by which an accessory factor aids selective export is unknown"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2022,"claim":"Defining EXP3's physical context answered which complex it belongs to, placing it in EPIC (with PV1 and PV2) and linking that complex to the PTEX translocon.","evidence":"Co-immunoprecipitation of binding partners from in vitro P. falciparum cultures","pmids":["35403274"],"confidence":"Medium","gaps":["Direct binding partners of EXP3 within EPIC not resolved (interface undefined)","Stoichiometry and architecture of EPIC unknown","Single-lab Co-IP without structural or reciprocal validation for EXP3 specifically"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2023,"claim":"Time-resolved proximity mapping addressed whether EXP3 engages cargo before export, capturing it near the exported protein SBP1 at a pre-export stage.","evidence":"TurboID-SBP1 proximity biotinylation with label-free quantitative proteomics in P. falciparum","pmids":["37772444"],"confidence":"Medium","gaps":["Proximity does not establish direct EXP3-SBP1 binding","No reciprocal Co-IP or mutagenesis confirming the interaction","Whether EXP3 acts on SBP1 handoff to PTEX is not tested"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":null,"claim":"The molecular activity of EXP3 within EPIC and how it selectively facilitates export of specific virulence effectors remain undefined.","evidence":"","pmids":[],"confidence":"Medium","gaps":["No biochemical activity assigned to EXP3","No structure or membrane topology","Specific effector cargo dependent on EXP3 not identified"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["Exported Protein-Interacting Complex (EPIC), with PV1 and PV2 [#1]","Associates with the PTEX protein export translocon (including P113) [#1]"],"partners":["PV1 [#1]","PV2 [#1]","P113 / PTEX [#1]","SBP1 (PRE-EXPORT PROXIMITY) [#0]"],"other_free_text":["Accessory, non-essential PTEX-associated factor at the PVM; dispensable for bulk export and in vitro fitness but implicated in export of virulence-relevant effectors in vivo [#2]","P. berghei ortholog PBANKA_0509000 localizes to the PVM in blood and liver stages [#3]"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"33272134","id":"PMC_33272134","title":"Comparative structural insight into prefoldin subunints of archaea and eukaryotes with special emphasis on unexplored prefoldin of Plasmodium falciparum.","date":"2020","source":"Journal of biomolecular structure & dynamics","url":"https://pubmed.ncbi.nlm.nih.gov/33272134","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["exported protein 3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41465491","id":"","title":"Plasmodium knowlesi Heat Shock Protein 90s: In Silico Analysis Reveals Unique Druggable Structural Features.","date":"2025","source":"International journal of molecular sciences","url":"https://pubmed.ncbi.nlm.nih.gov/41465491","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"35255125","id":"","title":"Transcriptome Analysis of Plasmodium falciparum Isolates From Benin Reveals Specific Gene Expression Associated With Cerebral Malaria.","date":"2022","source":"The Journal of infectious diseases","url":"https://pubmed.ncbi.nlm.nih.gov/35255125","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"37772444","id":"","title":"Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors.","date":"2023","source":"Journal of cell science","url":"https://pubmed.ncbi.nlm.nih.gov/37772444","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"35403274","id":"","title":"The Plasmodium falciparum parasitophorous vacuole protein P113 interacts with the parasite protein export machinery and maintains normal vacuole architecture.","date":"2022","source":"Molecular microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/35403274","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"37322481","id":"","title":"Histone modification analysis reveals common regulators of gene expression in liver and blood stage merozoites of Plasmodium parasites.","date":"2023","source":"Epigenetics & chromatin","url":"https://pubmed.ncbi.nlm.nih.gov/37322481","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"33793667","id":"","title":"Transport mechanisms at the malaria parasite-host cell interface.","date":"2021","source":"PLoS pathogens","url":"https://pubmed.ncbi.nlm.nih.gov/33793667","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34956312","id":"","title":"Absence of PEXEL-Dependent Protein Export in Plasmodium Liver Stages Cannot Be Restored by Gain of the HSP101 Protein Translocon ATPase.","date":"2021","source":"Frontiers in genetics","url":"https://pubmed.ncbi.nlm.nih.gov/34956312","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"29404413","id":"","title":"BioID Reveals Novel Proteins of the Plasmodium Parasitophorous Vacuole Membrane.","date":"2018","source":"mSphere","url":"https://pubmed.ncbi.nlm.nih.gov/29404413","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["EXP3"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":11478,"output_tokens":1292,"usd":0.026907,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6134,"output_tokens":2293,"usd":0.043998,"stage2_stop_reason":"end_turn"},"total_usd":0.070905,"stage1_batch_id":"msgbatch_01NE1MTa8x1hW7Lo4tAaNzY1","stage2_batch_id":"msgbatch_0141vaQdeFvbo2q39AinvXM9","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2023,\n      \"finding\": \"EXP3 (PF3D7_1024800) was identified as an interactor of the exported membrane protein SBP1 prior to its export (pre-export stage, 4 hpi), being 3-fold enriched at early time points in proximity-biotinylation experiments, consistent with its localization to the parasitophorous vacuole and a function in protein export.\",\n      \"method\": \"Time-resolved proximity biotinylation (TurboID fused to SBP1) combined with label-free quantitative proteomics\",\n      \"journal\": \"Journal of cell science\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — single proximity-biotinylation experiment in one lab; enrichment is quantitative but no reciprocal Co-IP or mutagenesis; EXP3 role in export supported by prior work cited in the same abstract\",\n      \"pmids\": [\"37772444\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"EXP3 (PF3D7_1024800) was identified as a component of the Exported Protein-Interacting Complex (EPIC), which also comprises PV1 and PV2, and EPIC was shown to interact with the PTEX protein export machinery (including P113) by immunoprecipitation studies in P. falciparum.\",\n      \"method\": \"Co-immunoprecipitation / immunoprecipitation of binding partners from in vitro P. falciparum cultures\",\n      \"journal\": \"Molecular microbiology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — Co-IP evidence from a single lab; EPIC membership and PTEX interaction reported in multiple independent studies (Batinovic et al. 2017 and Hakamada et al. 2020 both cited), supporting moderate preponderance\",\n      \"pmids\": [\"35403274\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2021,\n      \"finding\": \"EXP3 (PF3D7_1024800) was reported as an accessory (non-essential) component of the PTEX protein export machinery at the parasitophorous vacuole membrane; conditional depletion or disruption of EXP3 has little to no observable impact on protein export or parasite fitness in vitro, but accessory factors including EXP3 appear to aid export of virulence-relevant effector subsets in vivo.\",\n      \"method\": \"Conditional knockdown / genetic disruption with parasite growth and protein export assays (as reviewed from primary experimental literature cited)\",\n      \"journal\": \"PLoS pathogens\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — genetic loss-of-function data with defined phenotypic readout reported in multiple independent studies (review citing Batinovic et al. 2017 and others); non-essentiality in vitro replicated across labs\",\n      \"pmids\": [\"33793667\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2018,\n      \"finding\": \"The P. berghei ortholog of EXP3 (PBANKA_0509000) was localized to the parasitophorous vacuole membrane (PVM) during both blood stage and liver stage development, identified by BioID proximity biotinylation using BirA* fused to EXP1 on the PVM.\",\n      \"method\": \"BioID proximity biotinylation (BirA*-EXP1 fusion) followed by affinity purification and LC-MS/MS; confirmed by fluorescence microscopy during blood and liver stage development\",\n      \"journal\": \"mSphere\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct localization by two complementary methods (BioID proteomics and fluorescence imaging) in a single study; liver stage localization novel finding\",\n      \"pmids\": [\"29404413\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"EXP3 (PF3D7_1024800) is a parasitophorous vacuole membrane-associated protein that forms part of the Exported Protein-Interacting Complex (EPIC) together with PV1 and PV2; EPIC interacts with the core PTEX protein export translocon and with cargo proteins such as SBP1 prior to their export, and while EXP3 is dispensable for bulk protein export and parasite growth in vitro, it appears to facilitate export of specific virulence-relevant effectors in vivo; its ortholog in P. berghei also localizes to the PVM in liver stage parasites.\"\n}\n```","stage2_raw":"```json\n{\n  \"mechanistic_narrative\": \"EXP3 (PF3D7_1024800) is a parasitophorous vacuole membrane-associated protein of Plasmodium that functions in the compartment where parasite effector proteins are staged for export into the host erythrocyte [#0, #2]. In P. falciparum it is a component of the Exported Protein-Interacting Complex (EPIC), together with PV1 and PV2, and EPIC physically associates with the PTEX export translocon (including P113) [#1]; consistent with this, EXP3 is captured in proximity to the exported membrane protein SBP1 at an early, pre-export stage, placing it near cargo before translocation [#0]. Functionally, EXP3 behaves as an accessory rather than a core export factor: conditional depletion or disruption has little effect on bulk protein export or parasite fitness in vitro, while accessory factors of this class contribute to export of virulence-relevant effector subsets in vivo [#2]. The P. berghei ortholog (PBANKA_0509000) localizes to the PVM in both blood- and liver-stage parasites [#3]. Beyond its membership in EPIC and its PVM association, no direct enzymatic activity, structural model, or defined molecular mechanism for EXP3 itself has been characterized in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2018,\n      \"claim\": \"Establishing where the EXP3 ortholog resides answered whether it acts at the host-parasite interface, localizing it to the parasitophorous vacuole membrane across life-cycle stages.\",\n      \"evidence\": \"BioID proximity biotinylation with BirA*-EXP1 plus fluorescence microscopy in P. berghei blood and liver stages\",\n      \"pmids\": [\"29404413\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Localization shown for the P. berghei ortholog, not directly for PF3D7_1024800\",\n        \"Does not define a molecular function at the PVM\",\n        \"No membrane topology or orientation data\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2021,\n      \"claim\": \"Genetic loss-of-function testing addressed whether EXP3 is required for export, showing it is an accessory, non-essential PTEX-associated factor dispensable for bulk export in vitro but implicated in effector export in vivo.\",\n      \"evidence\": \"Conditional knockdown/genetic disruption with growth and export assays in P. falciparum (as reviewed from primary literature)\",\n      \"pmids\": [\"33793667\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Which specific effectors depend on EXP3 for export is not defined\",\n        \"The in vivo virulence contribution is inferred at the class level, not demonstrated for EXP3 individually\",\n        \"Mechanism by which an accessory factor aids selective export is unknown\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Defining EXP3's physical context answered which complex it belongs to, placing it in EPIC (with PV1 and PV2) and linking that complex to the PTEX translocon.\",\n      \"evidence\": \"Co-immunoprecipitation of binding partners from in vitro P. falciparum cultures\",\n      \"pmids\": [\"35403274\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Direct binding partners of EXP3 within EPIC not resolved (interface undefined)\",\n        \"Stoichiometry and architecture of EPIC unknown\",\n        \"Single-lab Co-IP without structural or reciprocal validation for EXP3 specifically\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"Time-resolved proximity mapping addressed whether EXP3 engages cargo before export, capturing it near the exported protein SBP1 at a pre-export stage.\",\n      \"evidence\": \"TurboID-SBP1 proximity biotinylation with label-free quantitative proteomics in P. falciparum\",\n      \"pmids\": [\"37772444\"],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"Proximity does not establish direct EXP3-SBP1 binding\",\n        \"No reciprocal Co-IP or mutagenesis confirming the interaction\",\n        \"Whether EXP3 acts on SBP1 handoff to PTEX is not tested\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The molecular activity of EXP3 within EPIC and how it selectively facilitates export of specific virulence effectors remain undefined.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"\",\n      \"gaps\": [\n        \"No biochemical activity assigned to EXP3\",\n        \"No structure or membrane topology\",\n        \"Specific effector cargo dependent on EXP3 not identified\"\n      ],\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [],\n    \"localization\": [\n      {\"term_id\": \"GO:0020002\", \"supporting_discovery_ids\": [0, 3]},\n      {\"term_id\": \"GO:0020003\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0065002\", \"supporting_discovery_ids\": [0, 1, 2]}\n    ],\n    \"complexes\": [\n      \"Exported Protein-Interacting Complex (EPIC), with PV1 and PV2 [#1]\",\n      \"Associates with the PTEX protein export translocon (including P113) [#1]\"\n    ],\n    \"partners\": [\n      \"PV1 [#1]\",\n      \"PV2 [#1]\",\n      \"P113 / PTEX [#1]\",\n      \"SBP1 (pre-export proximity) [#0]\"\n    ],\n    \"other_free_text\": [\n      \"Accessory, non-essential PTEX-associated factor at the PVM; dispensable for bulk export and in vitro fitness but implicated in export of virulence-relevant effectors in vivo [#2]\",\n      \"P. berghei ortholog PBANKA_0509000 localizes to the PVM in blood and liver stages [#3]\"\n    ]\n  }\n}\n```","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_1024800","name":null,"product":"exported protein 3","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_0509000","name":null,"product":"exported protein 3, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_0609300","name":null,"product":"exported protein 3, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"EXP3","evaluation":null}