{"gene":"PF3D7_0903500","run_date":"2026-09-08T19:44:17","timeline":{"discoveries":[{"year":2018,"finding":"NUP138 was identified as a nucleoporin component of the Plasmodium nuclear pore complex (NPC) via bioinformatic prediction combined with genetic tagging; it localizes to the nuclear periphery throughout the P. berghei life cycle and is characterized as an FG-repeat-containing nucleoporin.","method":"Bioinformatic identification combined with genetic tagging and immunofluorescence localization; cryo-electron tomography of Plasmodium NPCs","journal":"Scientific reports","confidence":"Medium","confidence_rationale":"Tier 3 / Moderate — direct localization by tagging in live parasites replicated in subsequent studies, but no functional mutagenesis or in vitro reconstitution","pmids":["30050042"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""},{"species":"Plasmodium falciparum","strain":""}]},{"year":2022,"finding":"NUP138 (the smallest known FG-repeat nucleoporin in Plasmodium) was used as a bait for proximity labeling (TurboID fusion at its endogenous locus in P. berghei); streptavidin labeling confirmed consistent biotinylation at the nuclear periphery, validating NUP138 as a nuclear pore component and demonstrating that TurboID fused to NUP138 labels the NPC environment in vivo.","method":"Endogenous C-terminal TurboID/BioID fusion tagging, streptavidin-based proximity labeling, immunofluorescence","journal":"mBio","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — proximity labeling with multiple biotin ligase variants at the endogenous locus, single lab, direct localization with functional read-out (biotinylation pattern)","pmids":["36040030"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2022,"finding":"Affinity purification of biotinylated proteins from a Nup313::TurboID line (using NUP138 as a known NPC component for comparison) confirmed NUP138 as part of the P. berghei NPC proteome by mass spectrometry.","method":"Proximity labeling (TurboID) followed by affinity purification and mass spectrometry","journal":"mBio","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — mass spectrometric identification within NPC proximity proteome, single lab","pmids":["36040030"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2024,"finding":"NUP138 tagged with smHA-3xHA at its endogenous locus in P. berghei localizes to the nuclear envelope throughout the 24-hour blood-stage replication cycle and is organized in a rosette structure around the centriolar plaque during mitosis, as revealed by ultrastructure expansion microscopy (U-ExM).","method":"Endogenous C-terminal smHA tagging, ultrastructure expansion microscopy (U-ExM) with NHS ester staining","journal":"mSphere","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — direct high-resolution localization by U-ExM with endogenous tagging, two independent publications (preprint and peer-reviewed), single lab","pmids":["39526784","38405843"],"is_preprint":false,"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2026,"finding":"NUP138 (PF3D7_0903500) co-purified with PfDPL (a cryptochrome-like protein) in P. falciparum, placing NUP138 in a multi-protein complex that also contains NUP313, NUP637, and NUP176, as well as chromatin remodelling and cytoskeletal proteins.","method":"Affinity purification coupled to mass spectrometry (co-purification with PfDPL bait)","journal":"Nature communications","confidence":"Low","confidence_rationale":"Tier 3 / Weak — single co-purification experiment, NUP138 is one of many co-purified proteins; no direct functional follow-up on NUP138 itself","pmids":["41986327"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]}],"current_model":"PF3D7_0903500 (NUP138) is an FG-repeat-containing nucleoporin that localizes to the nuclear envelope as a component of the Plasmodium nuclear pore complex throughout the blood-stage replication cycle; in P. berghei it is distributed around nuclei and forms a rosette structure around the centriolar plaque during mitosis, and it has been identified in NPC proximity proteomes and in a co-purification with the P. falciparum cryptochrome-like protein PfDPL, but no enzymatic activity, structural data, or direct functional role beyond NPC membership has been experimentally established for this protein."},"narrative":{"mechanistic_narrative":"PF3D7_0903500 (NUP138) is an FG-repeat-containing nucleoporin of the Plasmodium nuclear pore complex (NPC) that localizes to the nuclear periphery throughout the parasite life cycle [PMID:30050042]. It was identified as an NPC component by bioinformatic prediction combined with endogenous genetic tagging in P. berghei, where it is described as the smallest known FG-repeat nucleoporin [PMID:30050042, PMID:36040030], and its NPC membership has been corroborated by TurboID proximity labeling and mass spectrometry of the NPC proximity proteome [PMID:36040030]. High-resolution ultrastructure expansion microscopy shows NUP138 distributed around the nucleus across the 24-hour blood-stage replication cycle and organized into a rosette around the centriolar plaque during mitosis [PMID:39526784, PMID:38405843]. In P. falciparum, NUP138 co-purifies with the cryptochrome-like protein PfDPL alongside other nucleoporins (NUP313, NUP637, NUP176) and chromatin-remodelling and cytoskeletal proteins [PMID:41986327]. Beyond this structural membership in the NPC, no enzymatic activity, structural model, or dedicated functional role has been characterized for NUP138 in the available corpus.","teleology":[{"year":2018,"claim":"Establishing whether Plasmodium encodes recognizable nucleoporins was the first step in defining the parasite NPC; identifying NUP138 as an FG-repeat nucleoporin placed it structurally within the pore.","evidence":"Bioinformatic prediction plus endogenous genetic tagging and immunofluorescence localization in P. berghei, with cryo-electron tomography of Plasmodium NPCs","pmids":["30050042"],"confidence":"Medium","gaps":["No functional mutagenesis or knockout to test whether NUP138 is required for NPC assembly or nucleocytoplasmic transport","No in vitro reconstitution or structural placement of NUP138 within the pore scaffold","FG-repeat function (barrier/transport role) not directly demonstrated for NUP138"],"attribution":[{"species":"Plasmodium berghei","strain":""},{"species":"Plasmodium falciparum","strain":""}]},{"year":2022,"claim":"Confirming NUP138 as a bona fide pore component and a reliable spatial reference required an in vivo functional read-out; TurboID fused at the endogenous locus validated its nuclear-periphery position and its utility as an NPC bait.","evidence":"Endogenous C-terminal TurboID fusion with streptavidin-based proximity labeling and mass spectrometry of the NPC proximity proteome in P. berghei","pmids":["36040030"],"confidence":"Medium","gaps":["Proximity labeling reports neighborhood, not direct binary interactions or stoichiometry within the NPC","Single-lab data","Does not resolve which NPC subcomplex NUP138 belongs to"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2024,"claim":"Whether NUP138 distribution changes with the cell cycle was unknown; high-resolution imaging showed it persists at the nuclear envelope throughout blood-stage replication and forms a rosette around the centriolar plaque during mitosis, linking NUP138 to the mitotic spindle-pole region.","evidence":"Endogenous smHA-3xHA tagging and ultrastructure expansion microscopy (U-ExM) with NHS ester staining in P. berghei","pmids":["39526784","38405843"],"confidence":"Medium","gaps":["Functional significance of the centriolar-plaque rosette not tested","No mechanism linking NUP138 to spindle-pole or mitotic function","Single-lab observation"],"attribution":[{"species":"Plasmodium berghei","strain":""}]},{"year":2026,"claim":"Whether NUP138 associates with factors beyond the core pore was tested by co-purification, placing it in a P. falciparum complex containing PfDPL, other nucleoporins, and chromatin/cytoskeletal proteins.","evidence":"Affinity purification coupled to mass spectrometry using PfDPL as bait in P. falciparum","pmids":["41986327"],"confidence":"Low","gaps":["Single co-purification with NUP138 as one of many co-purified proteins; no reciprocal or direct interaction validation for NUP138","No functional follow-up on NUP138 within this complex","Physiological relevance of the PfDPL association to NUP138 undefined"],"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":null,"claim":"The functional role of NUP138 beyond structural NPC membership remains undefined: no loss-of-function phenotype, transport role, or mechanistic contribution to the mitotic rosette has been established.","evidence":"","pmids":[],"confidence":"Low","gaps":["No knockout, knockdown, or conditional-depletion phenotype for NUP138","No demonstrated role in nucleocytoplasmic transport or NPC assembly","No structural model or defined subcomplex assignment"],"attribution":[]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["Plasmodium nuclear pore complex (NPC)","PfDPL co-purifying complex (with NUP313, NUP637, NUP176, chromatin-remodelling and cytoskeletal proteins) [#4]"],"partners":["PFDPL (CRYPTOCHROME-LIKE PROTEIN) [#4]","NUP313 [#2, #4]","NUP637 [#4]","NUP176 [#4]"],"other_free_text":["Described as the smallest known FG-repeat nucleoporin in Plasmodium [#1]","Forms a rosette structure around the centriolar plaque during mitosis in P. berghei [#3]","No enzymatic activity, structural data, or loss-of-function phenotype established for PF3D7_0903500 in the available corpus"]}},"prefetch_data":{},"corpus_meta":[{"pmid":"30050042","id":"PMC_30050042","title":"Nuclear Pore Complex Components in the Malaria Parasite Plasmodium berghei.","date":"2018","source":"Scientific reports","url":"https://pubmed.ncbi.nlm.nih.gov/30050042","citation_count":20,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["curated_ref"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"38405843","id":"PMC_38405843","title":"Nuclear pore complexes undergo Nup221 exchange during blood stage asexual replication of Plasmodium parasites.","date":"2024","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/38405843","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"39526784","id":"","title":"Nuclear pore complexes undergo Nup221 exchange during blood-stage asexual replication of Plasmodium parasites.","date":"2024","source":"mSphere","url":"https://pubmed.ncbi.nlm.nih.gov/39526784","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41885428","id":"","title":"A heterologous marker-free selection approach for CRISPR/Cas9-based gene editing in the malaria parasite Plasmodium falciparum.","date":"2026","source":"mSphere","url":"https://pubmed.ncbi.nlm.nih.gov/41885428","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"41986327","id":"","title":"GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum.","date":"2026","source":"Nature communications","url":"https://pubmed.ncbi.nlm.nih.gov/41986327","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"36040030","id":"","title":"TurboID Identification of Evolutionarily Divergent Components of the Nuclear Pore Complex in the Malaria Model Plasmodium berghei.","date":"2022","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/36040030","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"39353279","id":"","title":"PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults.","date":"2024","source":"EBioMedicine","url":"https://pubmed.ncbi.nlm.nih.gov/39353279","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34604117","id":"","title":"Roles and Cellular Localization of GBP2 and NAB2 During the Blood Stage of Malaria Parasites.","date":"2021","source":"Frontiers in cellular and infection microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/34604117","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["NUP138"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":11440,"output_tokens":1475,"usd":0.028223,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":6398,"output_tokens":2465,"usd":0.046808,"stage2_stop_reason":"end_turn"},"total_usd":0.075031,"stage1_batch_id":"msgbatch_01SRp5hyRc82zNjddxyCCXGk","stage2_batch_id":"msgbatch_01K3BTmBazRo3pRrMvyaPMTY","note":"batch pricing = 50% of standard"},"stage1_raw":"```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2018,\n      \"finding\": \"NUP138 was identified as a nucleoporin component of the Plasmodium nuclear pore complex (NPC) via bioinformatic prediction combined with genetic tagging; it localizes to the nuclear periphery throughout the P. berghei life cycle and is characterized as an FG-repeat-containing nucleoporin.\",\n      \"method\": \"Bioinformatic identification combined with genetic tagging and immunofluorescence localization; cryo-electron tomography of Plasmodium NPCs\",\n      \"journal\": \"Scientific reports\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 3 / Moderate — direct localization by tagging in live parasites replicated in subsequent studies, but no functional mutagenesis or in vitro reconstitution\",\n      \"pmids\": [\"30050042\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"},\n        {\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"NUP138 (the smallest known FG-repeat nucleoporin in Plasmodium) was used as a bait for proximity labeling (TurboID fusion at its endogenous locus in P. berghei); streptavidin labeling confirmed consistent biotinylation at the nuclear periphery, validating NUP138 as a nuclear pore component and demonstrating that TurboID fused to NUP138 labels the NPC environment in vivo.\",\n      \"method\": \"Endogenous C-terminal TurboID/BioID fusion tagging, streptavidin-based proximity labeling, immunofluorescence\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — proximity labeling with multiple biotin ligase variants at the endogenous locus, single lab, direct localization with functional read-out (biotinylation pattern)\",\n      \"pmids\": [\"36040030\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"Affinity purification of biotinylated proteins from a Nup313::TurboID line (using NUP138 as a known NPC component for comparison) confirmed NUP138 as part of the P. berghei NPC proteome by mass spectrometry.\",\n      \"method\": \"Proximity labeling (TurboID) followed by affinity purification and mass spectrometry\",\n      \"journal\": \"mBio\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — mass spectrometric identification within NPC proximity proteome, single lab\",\n      \"pmids\": [\"36040030\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2024,\n      \"finding\": \"NUP138 tagged with smHA-3xHA at its endogenous locus in P. berghei localizes to the nuclear envelope throughout the 24-hour blood-stage replication cycle and is organized in a rosette structure around the centriolar plaque during mitosis, as revealed by ultrastructure expansion microscopy (U-ExM).\",\n      \"method\": \"Endogenous C-terminal smHA tagging, ultrastructure expansion microscopy (U-ExM) with NHS ester staining\",\n      \"journal\": \"mSphere\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — direct high-resolution localization by U-ExM with endogenous tagging, two independent publications (preprint and peer-reviewed), single lab\",\n      \"pmids\": [\"39526784\", \"38405843\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2026,\n      \"finding\": \"NUP138 (PF3D7_0903500) co-purified with PfDPL (a cryptochrome-like protein) in P. falciparum, placing NUP138 in a multi-protein complex that also contains NUP313, NUP637, and NUP176, as well as chromatin remodelling and cytoskeletal proteins.\",\n      \"method\": \"Affinity purification coupled to mass spectrometry (co-purification with PfDPL bait)\",\n      \"journal\": \"Nature communications\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — single co-purification experiment, NUP138 is one of many co-purified proteins; no direct functional follow-up on NUP138 itself\",\n      \"pmids\": [\"41986327\"],\n      \"is_preprint\": false,\n      \"attribution\": [\n        {\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}\n      ]\n    }\n  ],\n  \"current_model\": \"PF3D7_0903500 (NUP138) is an FG-repeat-containing nucleoporin that localizes to the nuclear envelope as a component of the Plasmodium nuclear pore complex throughout the blood-stage replication cycle; in P. berghei it is distributed around nuclei and forms a rosette structure around the centriolar plaque during mitosis, and it has been identified in NPC proximity proteomes and in a co-purification with the P. falciparum cryptochrome-like protein PfDPL, but no enzymatic activity, structural data, or direct functional role beyond NPC membership has been experimentally established for this protein.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"PF3D7_0903500 (NUP138) is an FG-repeat-containing nucleoporin of the Plasmodium nuclear pore complex (NPC) that localizes to the nuclear periphery throughout the parasite life cycle [#0]. It was identified as an NPC component by bioinformatic prediction combined with endogenous genetic tagging in P. berghei, where it is described as the smallest known FG-repeat nucleoporin [#0, #1], and its NPC membership has been corroborated by TurboID proximity labeling and mass spectrometry of the NPC proximity proteome [#1, #2]. High-resolution ultrastructure expansion microscopy shows NUP138 distributed around the nucleus across the 24-hour blood-stage replication cycle and organized into a rosette around the centriolar plaque during mitosis [#3]. In P. falciparum, NUP138 co-purifies with the cryptochrome-like protein PfDPL alongside other nucleoporins (NUP313, NUP637, NUP176) and chromatin-remodelling and cytoskeletal proteins [#4]. Beyond this structural membership in the NPC, no enzymatic activity, structural model, or dedicated functional role has been characterized for NUP138 in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2018,\n      \"claim\": \"Establishing whether Plasmodium encodes recognizable nucleoporins was the first step in defining the parasite NPC; identifying NUP138 as an FG-repeat nucleoporin placed it structurally within the pore.\",\n      \"evidence\": \"Bioinformatic prediction plus endogenous genetic tagging and immunofluorescence localization in P. berghei, with cryo-electron tomography of Plasmodium NPCs\",\n      \"pmids\": [\"30050042\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"No functional mutagenesis or knockout to test whether NUP138 is required for NPC assembly or nucleocytoplasmic transport\",\n        \"No in vitro reconstitution or structural placement of NUP138 within the pore scaffold\",\n        \"FG-repeat function (barrier/transport role) not directly demonstrated for NUP138\"\n      ],\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"},\n        {\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"Confirming NUP138 as a bona fide pore component and a reliable spatial reference required an in vivo functional read-out; TurboID fused at the endogenous locus validated its nuclear-periphery position and its utility as an NPC bait.\",\n      \"evidence\": \"Endogenous C-terminal TurboID fusion with streptavidin-based proximity labeling and mass spectrometry of the NPC proximity proteome in P. berghei\",\n      \"pmids\": [\"36040030\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Proximity labeling reports neighborhood, not direct binary interactions or stoichiometry within the NPC\",\n        \"Single-lab data\",\n        \"Does not resolve which NPC subcomplex NUP138 belongs to\"\n      ],\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2024,\n      \"claim\": \"Whether NUP138 distribution changes with the cell cycle was unknown; high-resolution imaging showed it persists at the nuclear envelope throughout blood-stage replication and forms a rosette around the centriolar plaque during mitosis, linking NUP138 to the mitotic spindle-pole region.\",\n      \"evidence\": \"Endogenous smHA-3xHA tagging and ultrastructure expansion microscopy (U-ExM) with NHS ester staining in P. berghei\",\n      \"pmids\": [\"39526784\", \"38405843\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\n        \"Functional significance of the centriolar-plaque rosette not tested\",\n        \"No mechanism linking NUP138 to spindle-pole or mitotic function\",\n        \"Single-lab observation\"\n      ],\n      \"attribution\": [\n        {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": 2026,\n      \"claim\": \"Whether NUP138 associates with factors beyond the core pore was tested by co-purification, placing it in a P. falciparum complex containing PfDPL, other nucleoporins, and chromatin/cytoskeletal proteins.\",\n      \"evidence\": \"Affinity purification coupled to mass spectrometry using PfDPL as bait in P. falciparum\",\n      \"pmids\": [\"41986327\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"Single co-purification with NUP138 as one of many co-purified proteins; no reciprocal or direct interaction validation for NUP138\",\n        \"No functional follow-up on NUP138 within this complex\",\n        \"Physiological relevance of the PfDPL association to NUP138 undefined\"\n      ],\n      \"attribution\": [\n        {\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}\n      ]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"The functional role of NUP138 beyond structural NPC membership remains undefined: no loss-of-function phenotype, transport role, or mechanistic contribution to the mitotic rosette has been established.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\n        \"No knockout, knockdown, or conditional-depletion phenotype for NUP138\",\n        \"No demonstrated role in nucleocytoplasmic transport or NPC assembly\",\n        \"No structural model or defined subcomplex assignment\"\n      ],\n      \"attribution\": []\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0017056\", \"supporting_discovery_ids\": [0, 1]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005643\", \"supporting_discovery_ids\": [0, 1, 2, 3]},\n      {\"term_id\": \"GO:0005635\", \"supporting_discovery_ids\": [0, 3]}\n    ],\n    \"pathway\": [],\n    \"complexes\": [\n      \"Plasmodium nuclear pore complex (NPC)\",\n      \"PfDPL co-purifying complex (with NUP313, NUP637, NUP176, chromatin-remodelling and cytoskeletal proteins) [#4]\"\n    ],\n    \"partners\": [\n      \"PfDPL (cryptochrome-like protein) [#4]\",\n      \"NUP313 [#2, #4]\",\n      \"NUP637 [#4]\",\n      \"NUP176 [#4]\"\n    ],\n    \"other_free_text\": [\n      \"Described as the smallest known FG-repeat nucleoporin in Plasmodium [#1]\",\n      \"Forms a rosette structure around the centriolar plaque during mitosis in P. berghei [#3]\",\n      \"No enzymatic activity, structural data, or loss-of-function phenotype established for PF3D7_0903500 in the available corpus\"\n    ]\n  }\n}","audit_flag":null,"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_0903500","name":null,"product":"nucleoporin NUP138, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_0417900","name":null,"product":"nucleoporin NUP138","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_0701200","name":null,"product":"nucleoporin NUP138, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"NUP138","evaluation":null}