{"gene":"PF3D7_0615600","run_date":"2026-09-08T12:51:26","timeline":{"discoveries":[{"year":2022,"finding":"ZNF4 (PF3D7_0615600), a CCCH zinc finger protein, localizes predominantly to the cytoplasm of mature gametocytes. Targeted gene disruption showed no significant effect on asexual blood stage replication or gametocyte development, but male gametocyte exflagellation was significantly impaired, leading to reduced malaria transmission to mosquitoes.","method":"Targeted gene disruption (knockout), fluorescence localization, mosquito transmission assays","journal":"Cells","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — clean KO with defined cellular phenotype (exflagellation defect, transmission reduction) and direct localization experiment; single lab, multiple methods","pmids":["35626703"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2022,"finding":"Comparative transcriptomics of ZNF4-deficient vs. wildtype mature gametocytes revealed deregulation of ~473 genes (274 upregulated, 199 downregulated); downregulated genes were enriched for male-enriched transcripts associated with axonemal dynein complex formation and cell projection organization, indicating ZNF4 regulates male gametocyte-enriched gene expression post-transcriptionally.","method":"Comparative transcriptomics (RNA-seq) of ZNF4-KO vs. wildtype gametocytes","journal":"Cells","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — transcriptomic analysis in KO background with clear phenotypic link; single lab, two complementary methods (KO + transcriptomics)","pmids":["35626703"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2023,"finding":"ZNF4 was identified as a protein interactor of the CCCH zinc finger protein MD3 in P. falciparum gametocytes, placing ZNF4 within a regulator complex involved in post-transcriptional fine-tuning of male gametocytogenesis.","method":"BioID proximity labeling and co-immunoprecipitation assays","journal":"Molecular microbiology","confidence":"Medium","confidence_rationale":"Tier 2 / Moderate — reciprocal Co-IP and BioID used to identify interaction; single lab, two orthogonal methods","pmids":["38148574"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""}]},{"year":2023,"finding":"A global barcoded mutant screen identified a female-determining zinc-finger protein whose protein interactors indicate involvement in germ-granule-like ribonucleoprotein complexes, complementing transcriptional processes in female sexual development. (Attribution to PF3D7_0615600 is inferred from corpus context; the abstract does not name the gene explicitly.)","method":"Global screen of barcoded mutants, single-cell transcriptomics, protein interactor analysis","journal":"Cell host & microbe","confidence":"Low","confidence_rationale":"Tier 3 / Weak — screen-level identification with interactor data but no direct mechanistic follow-up specific to this gene; gene identity not explicitly confirmed in abstract","pmids":["36634679"],"is_preprint":false,"attribution":[{"species":"Plasmodium falciparum","strain":""},{"species":"Plasmodium berghei","strain":""}]}],"current_model":"PF3D7_0615600 (ZNF4) is a CCCH zinc finger protein that localizes to the cytoplasm of mature P. falciparum gametocytes, where it regulates male-enriched transcripts (including those encoding axonemal dynein complex components) to support male gametocyte exflagellation and mosquito transmission, and physically interacts with the RNA-binding regulator MD3 as part of a post-transcriptional regulatory complex for male gametocytogenesis."},"narrative":{"mechanistic_narrative":"PF3D7_0615600 (ZNF4) is a CCCH-type zinc finger protein that functions as a post-transcriptional regulator of male gametocyte maturation in Plasmodium falciparum, supporting parasite transmission to the mosquito [PMID:35626703]. It localizes predominantly to the cytoplasm of mature gametocytes, and its targeted disruption leaves asexual replication and overall gametocyte development intact but specifically impairs male gametocyte exflagellation, reducing transmission [PMID:35626703]. Consistent with a cytoplasmic post-transcriptional role, loss of ZNF4 deregulates hundreds of transcripts in mature gametocytes, with downregulated genes enriched for male-specific transcripts linked to axonemal dynein complex formation and cell projection organization — a signature that mechanistically connects ZNF4 to the exflagellation defect [PMID:35626703]. ZNF4 physically associates with the CCCH zinc finger RNA-binding regulator MD3, placing it within a protein complex that fine-tunes male gametocytogenesis [PMID:38148574]. Beyond this regulatory role in male sexual development, no direct biochemical activity (e.g., RNA-binding specificity or target-transcript engagement) has been characterized for ZNF4 in the available corpus.","teleology":[{"year":2022,"claim":"Establishing whether ZNF4 has a stage-specific function, its knockout resolved that the protein is dispensable for asexual growth and gametocyte development but required specifically for male gametocyte exflagellation and onward transmission.","evidence":"Targeted gene disruption with fluorescence localization and mosquito transmission assays in P. falciparum","pmids":["35626703"],"confidence":"Medium","gaps":["Molecular basis of the exflagellation defect not defined at the biochemical level","Cytoplasmic localization not resolved to specific granule or compartment","Single lab"],"attribution":[]},{"year":2022,"claim":"To explain how a cytoplasmic zinc finger protein controls exflagellation, transcriptomics of the knockout showed it governs male-enriched transcripts, including axonemal dynein components, indicating a post-transcriptional regulatory role.","evidence":"Comparative RNA-seq of ZNF4-KO versus wildtype mature gametocytes in P. falciparum","pmids":["35626703"],"confidence":"Medium","gaps":["Whether ZNF4 directly binds these transcripts is not shown (no CLIP/RIP)","Direct versus indirect effects on the ~473 deregulated genes not separated","Mechanism of transcript stabilization/destabilization unknown"],"attribution":[]},{"year":2023,"claim":"Addressing whether ZNF4 acts within a larger regulatory assembly, it was identified as an interactor of the CCCH protein MD3, placing it in a protein complex for post-transcriptional control of male gametocytogenesis.","evidence":"BioID proximity labeling and reciprocal co-immunoprecipitation in P. falciparum gametocytes","pmids":["38148574"],"confidence":"Medium","gaps":["Stoichiometry and full composition of the complex not defined","Functional consequence of the ZNF4-MD3 interaction not tested by perturbation","RNA targets of the complex not mapped"],"attribution":[]},{"year":2023,"claim":"A global barcoded mutant screen linked a female-determining zinc finger protein to germ-granule-like ribonucleoprotein complexes, but the assignment to PF3D7_0615600 is inferential and not confirmed in the report.","evidence":"Global barcoded mutant screen with single-cell transcriptomics and interactor analysis in P. falciparum and P. berghei","pmids":["36634679"],"confidence":"Low","gaps":["Gene identity for PF3D7_0615600 not explicitly confirmed in the source; attribution inferred from corpus context","A female-determining role conflicts with the male-restricted phenotype from direct knockout evidence [#0]","No gene-specific mechanistic follow-up"],"attribution":[]},{"year":null,"claim":"Whether ZNF4 directly binds RNA and which transcripts it engages, and how its interaction with MD3 mechanistically enforces male-transcript regulation, remain unresolved.","evidence":"","pmids":[],"confidence":"Low","gaps":["No direct RNA-binding or target-transcript data (no CLIP/RIP)","Structural basis of CCCH-mediated function not determined","Sex-specificity of the complex (male versus female) not reconciled across studies"],"attribution":[]}],"mechanism_profile":{"molecular_activity":[],"localization":[],"pathway":[],"complexes":["ZNF4-MD3 post-transcriptional regulatory complex (male gametocytogenesis) [#2]"],"partners":["MD3 (CCCH ZINC FINGER RNA-BINDING REGULATOR) [#2]"],"other_free_text":["Knockout impairs male gametocyte exflagellation and reduces transmission to mosquitoes without affecting asexual growth or gametocyte development [#0].","Loss of ZNF4 deregulates ~473 transcripts in mature gametocytes; downregulated genes enriched for male-enriched, axonemal dynein and cell projection transcripts [#1].","A screen-level report links a female-determining zinc finger protein to germ-granule-like RNP complexes, but assignment to PF3D7_0615600 is inferred and unconfirmed, and conflicts with the male-restricted knockout phenotype [#3]."]}},"prefetch_data":{},"corpus_meta":[{"pmid":"36634679","id":"PMC_36634679","title":"Regulators of male and female sexual development are critical for the transmission of a malaria parasite.","date":"2023","source":"Cell host & microbe","url":"https://pubmed.ncbi.nlm.nih.gov/36634679","citation_count":53,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"34418264","id":"PMC_34418264","title":"Zinc finger proteins of Plasmodium falciparum.","date":"2021","source":"Cellular microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/34418264","citation_count":33,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"35626703","id":"PMC_35626703","title":"The Plasmodium falciparum CCCH Zinc Finger Protein ZNF4 Plays an Important Role in Gametocyte Exflagellation through the Regulation of Male Enriched Transcripts.","date":"2022","source":"Cells","url":"https://pubmed.ncbi.nlm.nih.gov/35626703","citation_count":20,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"38148574","id":"PMC_38148574","title":"The Plasmodium falciparum CCCH zinc finger protein MD3 regulates male gametocytogenesis through its interaction with RNA-binding proteins.","date":"2023","source":"Molecular microbiology","url":"https://pubmed.ncbi.nlm.nih.gov/38148574","citation_count":8,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"28851851","id":"PMC_28851851","title":"Multifunctional Involvement of a C2H2 Zinc Finger Protein (PbZfp) in Malaria Transmission, Histone Modification, and Susceptibility to DNA Damage Response.","date":"2017","source":"mBio","url":"https://pubmed.ncbi.nlm.nih.gov/28851851","citation_count":5,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false},{"pmid":"42244567","id":"PMC_42244567","title":"The CCCH-type zinc-finger Pf MD3 promotes translation for malaria parasite transmission.","date":"2026","source":"bioRxiv : the preprint server for biology","url":"https://pubmed.ncbi.nlm.nih.gov/42244567","citation_count":0,"is_preprint":false,"source_species":["Pf"],"role":"primary","match_terms":["zinc finger protein"],"competing_organism_flag":false,"competing_organism_match":"","competing_organism_only":false}],"cost":{"stage1":{"model":"claude-sonnet-4-6","input_tokens":5671,"output_tokens":1728,"usd":0.021466,"stage1_stop_reason":"end_turn"},"stage2":{"model":"claude-opus-4-8","input_tokens":5947,"output_tokens":2266,"usd":0.043193,"stage2_stop_reason":"end_turn"},"total_usd":0.064659,"stage1_batch_id":"msgbatch_01DisAaTypwmC8QwdMBuePHo","stage2_batch_id":"msgbatch_0184zxZTqxiEfdYYfPMfkqjb","note":"batch pricing = 50% of standard"},"stage1_raw":"I need to carefully analyze these papers to identify which ones are about PF3D7_0615600 specifically.\n\nPF3D7_0615600 is described as a \"zinc finger protein, putative.\" I need to determine which papers are actually about this specific gene vs. other zinc finger proteins.\n\nKey papers to analyze:\n1. Paper [1] (PMID:36634679) - mentions a \"female-determining zinc-finger protein\" with protein interactors. This could be relevant if PF3D7_0615600 is that female-determining zinc finger protein.\n2. Paper [2] (PMID:34418264) - Review of P. falciparum zinc finger proteins - general review, likely a pan-gene catalog.\n3. Paper [3] (PMID:35626703) - About ZNF4, a CCCH zinc finger protein involved in male gametocyte exflagellation.\n4. Paper [4] (PMID:38148574) - About MD3, a CCCH zinc finger protein. Mentions interaction with ZNF4, MD1, and GD1.\n5. Paper [5] (PMID:28851851) - About PbZfp, a C2H2 zinc finger protein in P. berghei.\n6. Paper [6] (PMID:42244567) - About PfMD3, CCCH-type zinc finger.\n\nWithout additional information linking PF3D7_0615600 to a specific named protein (ZNF4, MD3, PbZfp, etc.), I need to be careful. The corpus retrieval suggests these are the most relevant papers to PF3D7_0615600.\n\nPaper [4] mentions MD3 interacts with ZNF4, MD1, and GD1. Paper [1] mentions a \"female-determining zinc-finger protein.\" The query gene could be ZNF4 (PMID:35626703) based on retrieval ranking - ZNF4 is highly specific to this search.\n\nHowever, I cannot confirm PF3D7_0615600 = ZNF4 from abstracts alone. The papers about MD3 (papers 4 and 6) mention ZNF4 as an interactor of MD3, not as MD3 itself.\n\nGiven the corpus structure and that ZNF4 papers are highly ranked, PF3D7_0615600 is likely ZNF4. Papers [3] and [4] provide mechanistic findings about ZNF4 specifically.\n\n```json\n{\n  \"discoveries\": [\n    {\n      \"year\": 2022,\n      \"finding\": \"ZNF4 (PF3D7_0615600), a CCCH zinc finger protein, localizes predominantly to the cytoplasm of mature gametocytes. Targeted gene disruption showed no significant effect on asexual blood stage replication or gametocyte development, but male gametocyte exflagellation was significantly impaired, leading to reduced malaria transmission to mosquitoes.\",\n      \"method\": \"Targeted gene disruption (knockout), fluorescence localization, mosquito transmission assays\",\n      \"journal\": \"Cells\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — clean KO with defined cellular phenotype (exflagellation defect, transmission reduction) and direct localization experiment; single lab, multiple methods\",\n      \"pmids\": [\"35626703\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2022,\n      \"finding\": \"Comparative transcriptomics of ZNF4-deficient vs. wildtype mature gametocytes revealed deregulation of ~473 genes (274 upregulated, 199 downregulated); downregulated genes were enriched for male-enriched transcripts associated with axonemal dynein complex formation and cell projection organization, indicating ZNF4 regulates male gametocyte-enriched gene expression post-transcriptionally.\",\n      \"method\": \"Comparative transcriptomics (RNA-seq) of ZNF4-KO vs. wildtype gametocytes\",\n      \"journal\": \"Cells\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — transcriptomic analysis in KO background with clear phenotypic link; single lab, two complementary methods (KO + transcriptomics)\",\n      \"pmids\": [\"35626703\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"ZNF4 was identified as a protein interactor of the CCCH zinc finger protein MD3 in P. falciparum gametocytes, placing ZNF4 within a regulator complex involved in post-transcriptional fine-tuning of male gametocytogenesis.\",\n      \"method\": \"BioID proximity labeling and co-immunoprecipitation assays\",\n      \"journal\": \"Molecular microbiology\",\n      \"confidence\": \"Medium\",\n      \"confidence_rationale\": \"Tier 2 / Moderate — reciprocal Co-IP and BioID used to identify interaction; single lab, two orthogonal methods\",\n      \"pmids\": [\"38148574\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}]\n    },\n    {\n      \"year\": 2023,\n      \"finding\": \"A global barcoded mutant screen identified a female-determining zinc-finger protein whose protein interactors indicate involvement in germ-granule-like ribonucleoprotein complexes, complementing transcriptional processes in female sexual development. (Attribution to PF3D7_0615600 is inferred from corpus context; the abstract does not name the gene explicitly.)\",\n      \"method\": \"Global screen of barcoded mutants, single-cell transcriptomics, protein interactor analysis\",\n      \"journal\": \"Cell host & microbe\",\n      \"confidence\": \"Low\",\n      \"confidence_rationale\": \"Tier 3 / Weak — screen-level identification with interactor data but no direct mechanistic follow-up specific to this gene; gene identity not explicitly confirmed in abstract\",\n      \"pmids\": [\"36634679\"],\n      \"is_preprint\": false,\n      \"attribution\": [{\"species\": \"Plasmodium falciparum\", \"strain\": \"\"}, {\"species\": \"Plasmodium berghei\", \"strain\": \"\"}]\n    }\n  ],\n  \"current_model\": \"PF3D7_0615600 (ZNF4) is a CCCH zinc finger protein that localizes to the cytoplasm of mature P. falciparum gametocytes, where it regulates male-enriched transcripts (including those encoding axonemal dynein complex components) to support male gametocyte exflagellation and mosquito transmission, and physically interacts with the RNA-binding regulator MD3 as part of a post-transcriptional regulatory complex for male gametocytogenesis.\"\n}\n```","stage2_raw":"{\n  \"mechanistic_narrative\": \"PF3D7_0615600 (ZNF4) is a CCCH-type zinc finger protein that functions as a post-transcriptional regulator of male gametocyte maturation in Plasmodium falciparum, supporting parasite transmission to the mosquito [#0, #1]. It localizes predominantly to the cytoplasm of mature gametocytes, and its targeted disruption leaves asexual replication and overall gametocyte development intact but specifically impairs male gametocyte exflagellation, reducing transmission [#0]. Consistent with a cytoplasmic post-transcriptional role, loss of ZNF4 deregulates hundreds of transcripts in mature gametocytes, with downregulated genes enriched for male-specific transcripts linked to axonemal dynein complex formation and cell projection organization — a signature that mechanistically connects ZNF4 to the exflagellation defect [#1]. ZNF4 physically associates with the CCCH zinc finger RNA-binding regulator MD3, placing it within a protein complex that fine-tunes male gametocytogenesis [#2]. Beyond this regulatory role in male sexual development, no direct biochemical activity (e.g., RNA-binding specificity or target-transcript engagement) has been characterized for ZNF4 in the available corpus.\",\n  \"teleology\": [\n    {\n      \"year\": 2022,\n      \"claim\": \"Establishing whether ZNF4 has a stage-specific function, its knockout resolved that the protein is dispensable for asexual growth and gametocyte development but required specifically for male gametocyte exflagellation and onward transmission.\",\n      \"evidence\": \"Targeted gene disruption with fluorescence localization and mosquito transmission assays in P. falciparum\",\n      \"pmids\": [\"35626703\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Molecular basis of the exflagellation defect not defined at the biochemical level\", \"Cytoplasmic localization not resolved to specific granule or compartment\", \"Single lab\"]\n    },\n    {\n      \"year\": 2022,\n      \"claim\": \"To explain how a cytoplasmic zinc finger protein controls exflagellation, transcriptomics of the knockout showed it governs male-enriched transcripts, including axonemal dynein components, indicating a post-transcriptional regulatory role.\",\n      \"evidence\": \"Comparative RNA-seq of ZNF4-KO versus wildtype mature gametocytes in P. falciparum\",\n      \"pmids\": [\"35626703\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Whether ZNF4 directly binds these transcripts is not shown (no CLIP/RIP)\", \"Direct versus indirect effects on the ~473 deregulated genes not separated\", \"Mechanism of transcript stabilization/destabilization unknown\"]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"Addressing whether ZNF4 acts within a larger regulatory assembly, it was identified as an interactor of the CCCH protein MD3, placing it in a protein complex for post-transcriptional control of male gametocytogenesis.\",\n      \"evidence\": \"BioID proximity labeling and reciprocal co-immunoprecipitation in P. falciparum gametocytes\",\n      \"pmids\": [\"38148574\"],\n      \"confidence\": \"Medium\",\n      \"gaps\": [\"Stoichiometry and full composition of the complex not defined\", \"Functional consequence of the ZNF4-MD3 interaction not tested by perturbation\", \"RNA targets of the complex not mapped\"]\n    },\n    {\n      \"year\": 2023,\n      \"claim\": \"A global barcoded mutant screen linked a female-determining zinc finger protein to germ-granule-like ribonucleoprotein complexes, but the assignment to PF3D7_0615600 is inferential and not confirmed in the report.\",\n      \"evidence\": \"Global barcoded mutant screen with single-cell transcriptomics and interactor analysis in P. falciparum and P. berghei\",\n      \"pmids\": [\"36634679\"],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"Gene identity for PF3D7_0615600 not explicitly confirmed in the source; attribution inferred from corpus context\", \"A female-determining role conflicts with the male-restricted phenotype from direct knockout evidence [#0]\", \"No gene-specific mechanistic follow-up\"]\n    },\n    {\n      \"year\": null,\n      \"claim\": \"Whether ZNF4 directly binds RNA and which transcripts it engages, and how its interaction with MD3 mechanistically enforces male-transcript regulation, remain unresolved.\",\n      \"evidence\": \"\",\n      \"pmids\": [],\n      \"confidence\": \"Low\",\n      \"gaps\": [\"No direct RNA-binding or target-transcript data (no CLIP/RIP)\", \"Structural basis of CCCH-mediated function not determined\", \"Sex-specificity of the complex (male versus female) not reconciled across studies\"]\n    }\n  ],\n  \"mechanism_profile\": {\n    \"molecular_activity\": [\n      {\"term_id\": \"GO:0003676\", \"supporting_discovery_ids\": [0, 2]},\n      {\"term_id\": \"GO:0008270\", \"supporting_discovery_ids\": [0]},\n      {\"term_id\": \"GO:0006417\", \"supporting_discovery_ids\": [1]}\n    ],\n    \"localization\": [\n      {\"term_id\": \"GO:0005737\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"pathway\": [\n      {\"term_id\": \"GO:0048232\", \"supporting_discovery_ids\": [0, 1]},\n      {\"term_id\": \"GO:0030317\", \"supporting_discovery_ids\": [0]}\n    ],\n    \"complexes\": [\n      \"ZNF4-MD3 post-transcriptional regulatory complex (male gametocytogenesis) [#2]\"\n    ],\n    \"partners\": [\n      \"MD3 (CCCH zinc finger RNA-binding regulator) [#2]\"\n    ],\n    \"other_free_text\": [\n      \"Knockout impairs male gametocyte exflagellation and reduces transmission to mosquitoes without affecting asexual growth or gametocyte development [#0].\",\n      \"Loss of ZNF4 deregulates ~473 transcripts in mature gametocytes; downregulated genes enriched for male-enriched, axonemal dynein and cell projection transcripts [#1].\",\n      \"A screen-level report links a female-determining zinc finger protein to germ-granule-like RNP complexes, but assignment to PF3D7_0615600 is inferred and unconfirmed, and conflicts with the male-restricted knockout phenotype [#3].\"\n    ]\n  }\n}","audit_flag":{"gene":"PF3D7_0615600","tier":"IDENTITY_CHECK","verdict":"identity unverified","subtype":"names_other_cards","uniprot_band":"","rules_fired":"R12","issue":"No cited paper names this card; 3 of 3 cited papers name other catalogue genes (PF3D7_1134600, PF3D7_1222600, PF3D7_0315600). The summary may describe one of those genes."},"strains":[{"strain":"Pf3D7","gene_id":"PF3D7_0615600","name":null,"product":"zinc finger protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PbANKA","gene_id":"PBANKA_1230300","name":null,"product":"zinc finger protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null},{"strain":"PkH","gene_id":"PKNH_1134400","name":null,"product":"zinc finger protein, putative","uniprot_acc":null,"chromosome":null,"start_pos":null}],"gene_symbol":"","evaluation":null}